INT171562

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 12.12
Pain Relevance 5.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
plasma 1
macrophages 1
lymphocytes 1
eosinophils 1
T lymphocytes 1
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 488 100.00 Very High Very High Very High
Inflammation 432 100.00 Very High Very High Very High
Inflammatory mediators 7 99.40 Very High Very High Very High
Cholecystokinin 53 99.28 Very High Very High Very High
chemokine 67 99.16 Very High Very High Very High
rheumatoid arthritis 156 97.94 Very High Very High Very High
alcohol 2 92.92 High High
Arthritis 130 92.88 High High
Endocannabinoid 18 91.12 High High
Inflammatory stimuli 5 89.76 High High
Disease Link Frequency Relevance Heat
Asthma 758 100.00 Very High Very High Very High
INFLAMMATION 457 100.00 Very High Very High Very High
Infection 91 100.00 Very High Very High Very High
Prostate Cancer 51 99.04 Very High Very High Very High
Cancer 167 98.20 Very High Very High Very High
Hypersensitivity 129 98.08 Very High Very High Very High
Rheumatoid Arthritis 160 97.94 Very High Very High Very High
Syndrome 66 97.04 Very High Very High Very High
Nephritis 1 96.52 Very High Very High Very High
Diabetes Mellitus 13 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, anti-IL-4 and isotype control antibodies (Caltag Laboratories) were added during the permeabilization step (1 ?
Regulation (control) of IL-4
1) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0 Pain Relevance 0.10
To test this hypothesis, we compared the effect of RANKL + M-CSF with GM-CSF + IL-4 on CD16 surface expression.
Regulation (effect) of IL-4
2) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.29 Pain Relevance 0.15
, RANTES, histamine: Beckman-Coulter, Krefeld, Germany; IL-4, IL-10, IL-13, soluble intracellular adhesion molecule-1 (sICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM): Bender MedSystems, Vienna, Austria; IL-5, IL-6 high sensitivity, IL-10 high sensitivity, IL-12 p40/p70, soluble leukocytic (sL)-selectin, sE-selectin: R&D Systems GmbH, Wiesbaden, Germany; IL-2, IL-2-receptor, serum and urine neopterin: DPC Biermann GmbH, Bad Nauheim, Germany; IL-4 high sensitivity, IL-11: Natutec, Frankfurt, Germany; IL-12 p70, IL-13: Biozol Diagnostica Ver-trieb GmbH, Eching, Germany; C5a: Behringwerke AG, Marburg, Germany].
Regulation (sensitivity) of IL-4 in urine associated with adhesions
3) Confidence 0.26 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.24 Pain Relevance 0
In an animal model of asthma there is increased IL-19 expression and transfer of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13, however, IL-19 up-regulated IL-13 in “asthmatic” mice [260].
Neg (not) Regulation (regulated) of IL-4 associated with asthma
4) Confidence 0.19 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.55 Pain Relevance 0.21
These events ultimately lead to the release of important cytokines such as IL-4 and IL-13 critical for immunoglobulin E (IgE) production.
Regulation (critical) of IL-4 associated with cytokine
5) Confidence 0.17 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.68 Pain Relevance 0.29
The upregulation of IP-10 mRNA observed here in monkeys challenged by IL-4 inhalation warrants further investigation to determine the cell type and mechanism of IL-4 regulation of IP-10 in vivo.
Regulation (regulation) of IL-4
6) Confidence 0.16 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0.05 Pain Relevance 0.08
, interleukin (IL)-2, IL-4, IL-5 and IL-10 were measured in supernatants using a cytometric bead array (BD Biosciences).
Regulation (measured) of IL-4
7) Confidence 0.12 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.38 Pain Relevance 0.20
Because of the importance of Th-2 cytokines, IL-4, IL-5, IL-9, and IL-13, strategies aimed at inhibiting their production or effects have been tried in human clinical trials (Table).
Regulation (importance) of IL-4 associated with cytokine
8) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.66 Pain Relevance 0.41
The present data motivate studies designed to determine how IL-4 regulates FAAH in prostate cancer cells compared to lymphocytes, whether stromal IL-4 immunoreactivity (and/or expression of IL-4 receptors in the tumour epithelia) correlates with tumour epithelial FAAH-IR in prostate cancer tissue, and which other components of the tumour microenvironment are potential regulators of the endocannabinoid system.



Regulation (immunoreactivity) of IL-4 in lymphocytes associated with endocannabinoid, cancer and prostate cancer
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.90 Pain Relevance 0.05
, IL-4, IL-5, IL-8, RANTES and eotaxins, thought to be important in asthma pathogenesis, are regulated through activation of p38 MAPK. p38 MAPK can affect the transcription of these genes but also has major effects on mRNA stability.
Regulation (regulated) of IL-4 associated with asthma
10) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.91 Pain Relevance 0.44
Many elements of the allergic reaction, including the production of IgE antibodies and the recruitment and activation of eosinophils, depend on Type 2 cytokines, such as IL-4, IL-5, and IL-13.
Regulation (depend) of IL-4 in eosinophils associated with hypersensitivity and cytokine
11) Confidence 0.07 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.19 Pain Relevance 0.52
No statistically significant changes in IL-4 levels were observed with MTB or CW treatment in the presence of either mitogen, compared to mitogen treatment alone.
Neg (No) Regulation (changes) of IL-4
12) Confidence 0.06 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0 Pain Relevance 0.11
Release of IL-10 increased from the choriodecidua in response to LPS, but no significant response was observed for the other anti-inflammatory cytokines, IL-4 and TGF-?.
Neg (no) Regulation (response) of IL-4 associated with inflammation and cytokine
13) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.89 Pain Relevance 0.55
Vitamin D3 may exert major immunomodulatory effects in RA [190] that are possibly based on the effects on activated synovial macrophages, resulting in positive regulation of the anti-inflammatory cytokines IL-4 and TGF-?
Regulation (regulation) of cytokines IL-4 in macrophages associated with inflammation, rheumatoid arthritis and cytokine
14) Confidence 0.05 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.84 Pain Relevance 0.44
The elevation of IgE in these disorders may be due to dysregulation of the IL-4-IL-13 axis.
Regulation (dysregulation) of IL-4
15) Confidence 0.04 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 2.01 Pain Relevance 0.31
This study doesn't conclude that dual influence of IL-4 and TGF-?
Regulation (influence) of IL-4
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.24 Pain Relevance 0.17
IL-4 is the main cytokine responsible for IgE production, inducing antibody isotype switching from IgG and IgM to IgE [10].
Regulation (responsible) of IL-4 associated with cytokine
17) Confidence 0.03 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.53 Pain Relevance 0.12
These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21.
Regulation (include) of IL-4 associated with cytokine
18) Confidence 0.03 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.19 Pain Relevance 0.30
In a mouse model, McDermott and colleagues [29] demonstrated that upper gut inflammation, via specific control of CD4+ T lymphocytes and related inflammatory cytokines (interleukin-3 and interleukin-4), can upregulate CCK-expressing cells, increase plasma CCK concentrations, and reduce energy intake.
Regulation (control) of interleukin-4 in T lymphocytes associated with inflammation, cholecystokinin and cytokine
19) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1794491 Disease Relevance 0.85 Pain Relevance 0.67
To understand if CQ modulated the cytokine response to DENV infection, plasma concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, GM-CSF, INF-?
Regulation (modulated) of IL-4 in plasma associated with infection and cytokine
20) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919376 Disease Relevance 0.73 Pain Relevance 0.22

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