INT171594

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (APOC3) transport (APOC3) extracellular space (APOC3)
small molecule metabolic process (APOC3) extracellular region (APOC3) lipid metabolic process (APOC3)
Anatomy Link Frequency
plasma 2
Shoulders 1
APOC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 136 100.00 Very High Very High Very High
Hyperlipidemia 158 99.36 Very High Very High Very High
Obesity 20 95.76 Very High Very High Very High
Hypertension 54 89.44 High High
Disorder Of Lipid Metabolism 112 86.56 High High
Inflammatory Bowel Disease 12 80.72 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 79.88 Quite High
Nicotine Addiction 12 38.48 Quite Low
Targeted Disruption 16 38.12 Quite Low
Diabetes Mellitus 28 29.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dallinga-Thie et al [22,23] and Shoulders et al [24,25] reported an association between levels of apoCIII and S2 allele.
apoCIII Binding (association) of in Shoulders
1) Confidence 0.37 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.39 Pain Relevance 0
Logistic analysis revealed a significant association of APOC3 S2 allele with hypertriglyceridemia (Table 3).
APOC3 Binding (association) of associated with hyperlipidemia
2) Confidence 0.37 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.82 Pain Relevance 0
Ours is the first study on Asian Indians to report a strong association of APOC3 S2 allele with hypertriglyceridemia in Indians.
APOC3 Binding (association) of associated with hyperlipidemia
3) Confidence 0.37 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.56 Pain Relevance 0
To determine the association of APOC3 SstI polymorphism with TG levels, the study population was divided into NTG and HTG groups.
APOC3 Binding (association) of associated with hyperlipidemia
4) Confidence 0.36 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.84 Pain Relevance 0
Based on the suggestive linkage of the APOC3-Sac1 locus to CAD and the association of minor allele with plasma TG levels, this study was subsequently extended to include three additional SNPs in the Apo11q gene cluster.
APOC3 Binding (association) of in plasma associated with coronary artery disease
5) Confidence 0.31 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.59 Pain Relevance 0
Results from linear regression analysis showed that APOC3-Sac1 SNP was the only significant contributory genetic marker among the 4 SNPs and was able to account for about 2.8% (P = 0.005) of the variation in plasma TG levels.
APOC3 Binding (account) of in plasma
6) Confidence 0.31 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.69 Pain Relevance 0

General Comments

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