INT171597

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.18
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (APOC3) transport (APOC3) extracellular space (APOC3)
small molecule metabolic process (APOC3) extracellular region (APOC3) lipid metabolic process (APOC3)
Anatomy Link Frequency
intestine 3
plasma 2
Shoulders 1
arm 1
APOC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 30 99.64 Very High Very High Very High
Inflammation 14 5.00 Very Low Very Low Very Low
Angina 12 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Endocannabinoid 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 148 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 138 100.00 Very High Very High Very High
Hyperlipidemia 236 99.60 Very High Very High Very High
Targeted Disruption 24 99.28 Very High Very High Very High
Syndrome 6 92.20 High High
Inflammatory Bowel Disease 12 83.76 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 79.88 Quite High
Obesity 34 75.52 Quite High
Nicotine Addiction 12 38.48 Quite Low
Hypertension 54 30.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human APOC3 gene expression is controlled by positive and negative elements that are spread through out the APOA1-C3-A4 gene cluster on the long arm of chromosome 11 [39].
Gene_expression (expression) of APOC3 in arm
1) Confidence 0.77 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.41 Pain Relevance 0
Overexpression of apoCIII produces hypertriglyceridemia in transgenic mouse models via inhibition of clearance of TG-rich particles [4].
Gene_expression (Overexpression) of apoCIII associated with targeted disruption and hyperlipidemia
2) Confidence 0.77 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.55 Pain Relevance 0
Apolipoprotein CIII (apoCIII protein; APOC3 gene) is a 79 amino acids long glycoprotein that is synthesized predominantly in the liver and to a lesser degree in the intestine [1].
Gene_expression (synthesized) of APOC3 in intestine associated with disorder of lipid metabolism
3) Confidence 0.60 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.10 Pain Relevance 0
Dallinga-Thie et al [22,23] and Shoulders et al [24,25] reported an association between levels of apoCIII and S2 allele.
Gene_expression (levels) of apoCIII in Shoulders
4) Confidence 0.60 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.39 Pain Relevance 0
Apolipoprotein CIII (apoCIII protein; APOC3 gene) is a 79 amino acids long glycoprotein that is synthesized predominantly in the liver and to a lesser degree in the intestine [1].
Gene_expression (synthesized) of apoCIII in intestine associated with disorder of lipid metabolism
5) Confidence 0.60 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.10 Pain Relevance 0
Apolipoprotein CIII (apoCIII protein; APOC3 gene) is a 79 amino acids long glycoprotein that is synthesized predominantly in the liver and to a lesser degree in the intestine [1].
Gene_expression (synthesized) of Apolipoprotein CIII in intestine associated with disorder of lipid metabolism
6) Confidence 0.60 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.10 Pain Relevance 0
Based on the suggestive linkage of the APOC3-Sac1 locus to CAD and the association of minor allele with plasma TG levels, this study was subsequently extended to include three additional SNPs in the Apo11q gene cluster.
Gene_expression (levels) of APOC3 in plasma associated with coronary artery disease
7) Confidence 0.56 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.60 Pain Relevance 0
Therefore, the present study aimed to elucidate the relationship of four single nucleotide polymorphisms (SNPs) in the Apo11q cluster, namely the -75G>A, +83C>T SNPs in the APOA1 gene, the Sac1 SNP in the APOC3 gene and the S19W variant in the APOA5 gene to plasma lipids and CAD in 190 affected sibling pairs (ASPs) belonging to Asian Indian families with a strong CAD history.


Gene_expression (gene) of APOC3 in plasma associated with coronary artery disease
8) Confidence 0.56 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2556320 Disease Relevance 0.52 Pain Relevance 0
agonists downregulate the expression of LPL inhibitor APOC3, supposedly via mechanisms involving the transcription factors REV-ERB?
Gene_expression (expression) of APOC3 associated with agonist
9) Confidence 0.34 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.33 Pain Relevance 0.20

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