INT171605

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.14
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx2) DNA binding (Runx2) transcription factor binding (Runx2)
cytoplasm (Runx2)
Anatomy Link Frequency
chondrocyte 1
cortex 1
Runx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 32 99.28 Very High Very High Very High
Inflammatory response 6 69.36 Quite High
cytokine 17 62.72 Quite High
chemokine 2 58.96 Quite High
depression 3 40.08 Quite Low
positron emission tomography 17 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
cocaine 8 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 19 100.00 Very High Very High Very High
INFLAMMATION 35 99.28 Very High Very High Very High
Hypertrophy 6 98.20 Very High Very High Very High
Targeted Disruption 19 97.68 Very High Very High Very High
Asthma 33 97.00 Very High Very High Very High
Apoptosis 4 96.80 Very High Very High Very High
Fabry Disease 25 90.76 High High
Osteoporosis 34 82.00 Quite High
Convulsion 54 65.68 Quite High
Tibia Fractures 3 55.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus HDAC4 repression of RUNX2 and MEF2C is critical for normal bone development.
Negative_regulation (repression) of RUNX2 associated with repression
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.40 Pain Relevance 0
Therefore it is highly likely that the expressed HDAC4 1-747 retains its binding to and repression of MEF2C and Runx2 in vivo, explaining the lack of chondrocyte hypertrophy in our mutant mice.
Negative_regulation (repression) of Runx2 in chondrocyte associated with hypertrophy and repression
2) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.77 Pain Relevance 0
Among the up-regulated genes were 3 associated with inhibition of proliferation (Gpnmb, Setd8, Runx2) and 1 promoting inflammatory and immune responses (Pik3cd), as well as 4 asthma-related genes (Arg1, Ccl24, Slc7a2, Mcpt1) identifiable only through qRT-PCR.
Negative_regulation (inhibition) of Runx2 associated with asthma and inflammation
3) Confidence 0.40 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.53 Pain Relevance 0.17
We also observed a significant down-regulation of SOX9 and RUNX2 in both of these mice (Figure 2L and 2M).
Negative_regulation (down-regulation) of RUNX2
4) Confidence 0.14 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.29 Pain Relevance 0
A reduction in rCBF was also found when the analysis was restricted to the visual cortex (p < 0.001) with no areas of significantly decreased rCBF in the placebo group.
Negative_regulation (reduction) of rCBF in cortex
5) Confidence 0.01 Published 2002 Journal BMC Neurol Section Body Doc Link PMC116601 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox