INT171610

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Sh2d1b2)
Sh2d1b2 (Mus musculus)
Pain Link Frequency Relevance Heat
peripheral neuropathy 6 81.24 Quite High
Peripheral nervous system 4 5.88 Low Low
positron emission tomography 17 5.00 Very Low Very Low Very Low
Neuropathic pain 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
hypoalgesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 61 99.92 Very High Very High Very High
Gauchers Disease 14 82.96 Quite High
Peripheral Neuropathy 6 81.24 Quite High
Diarrhoea 2 80.32 Quite High
Disease Progression 4 69.44 Quite High
Targeted Disruption 5 56.24 Quite High
Disease 28 50.88 Quite High
Heart Disease 3 25.24 Quite Low
Cerebrovascular Disease 4 12.80 Low Low
Neuropathic Pain 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This distinction suggests that a combination of ERT and SRT may be a more beneficial approach to managing Fabry disease.
Negative_regulation (combination) of ERT associated with fabry disease
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.96 Pain Relevance 0.04
As well as just adding SRT to the existing ERT, we evaluated the potential for a reduced frequency of ERT in combination with SRT (ERT4+SRT) as being another treatment option.
Negative_regulation (frequency) of ERT
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.19 Pain Relevance 0
ERT resulted in a significantly lower absolute rCBF during visual stimulation in the treatment group compared to the placebo (Figure 3, p < 0.001) while no significantly decreased areas of rCBF were found in the placebo group.
Negative_regulation (resulted) of ERT
3) Confidence 0.10 Published 2002 Journal BMC Neurol Section Body Doc Link PMC116601 Disease Relevance 0.10 Pain Relevance 0

General Comments

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