INT171614

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 3.04
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx2) DNA binding (Runx2) transcription factor binding (Runx2)
cytoplasm (Runx2)
Anatomy Link Frequency
osteoblast 2
anterior 2
posterior 2
dentin 2
bone marrow 1
Runx2 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 12 93.20 High High
Pain 6 67.92 Quite High
agonist 9 59.56 Quite High
Inflammation 24 12.00 Low Low
positron emission tomography 102 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Neuropathic pain 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Lasting pain 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 150 100.00 Very High Very High Very High
Osteoporosis 103 100.00 Very High Very High Very High
Cleidocranial Dysplasia 31 83.04 Quite High
Pain 8 67.92 Quite High
Holoprosencephaly 2 61.52 Quite High
Insulin Resistance 1 56.24 Quite High
Obesity 32 55.32 Quite High
Hypercalcemia 14 52.56 Quite High
Congenital Anomalies 44 52.00 Quite High
Fibrodysplasia Ossificans Progressiva 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, primary bone marrow cells from heterozygotes showed increased osteoblastogenesis in the absence of differentiating agents, with upregulation of key molecules for osteoblast differentiation, Runx2, osterix, and LRP5.
Positive_regulation (upregulation) of Runx2 in bone marrow associated with osteoporosis
1) Confidence 0.63 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.35 Pain Relevance 0.03
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (elevated) of Runt related transcription factor 2 in dentin
2) Confidence 0.51 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
Additional cis-acting regulatory sequences located 200 and 400 kb upstream of exon 1 have been identified that act as enhancers of the RUNX2 gene [Stock and Otto, 2005].
Positive_regulation (enhancers) of RUNX2
3) Confidence 0.50 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.26 Pain Relevance 0
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (increased) of Runx2 in dentin
4) Confidence 0.37 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.05
RUNX2 was upregulated in treated PB-hMSCs, with respect to control, while SP7, was downregulated.
Positive_regulation (upregulated) of RUNX2
5) Confidence 0.36 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.25 Pain Relevance 0
RUNX2 at the early stage of embryogenesis determines the osteoblast lineage from multipotent mesenchymal stem cells.[19] Thus we demonstrate that osteoplant increases the activity of the RUNX2 gene, which is a key point in osteodifferentiation.
Positive_regulation (increases) of RUNX2 gene in stem cells associated with osteoporosis
6) Confidence 0.36 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.49 Pain Relevance 0
The results of real-time PCR showed that after one week of treatment, compared to the control cells, the osteogenic transcription factors RUNX2 and two bone-related genes BGLAP and SPP1 were upregulated.
Positive_regulation (upregulated) of RUNX2
7) Confidence 0.24 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.16 Pain Relevance 0.07
The osteoplant causes induction of osteoblast transcriptional factors such as osterix (RUNX2), and of bone-related genes such as osteopontin (SPP1) and osteocalcin (BGLAP).
Positive_regulation (induction) of RUNX2 in osteoblast associated with osteoporosis
8) Confidence 0.24 Published 2010 Journal Journal of Indian Society of Periodontology Section Abstract Doc Link PMC2933523 Disease Relevance 0.28 Pain Relevance 0
Finally, to confirm the differentiation of TSCs into osteocytes in osteogenic medium, induction of Runx2, an osteoblast specific gene, was examined by qRT-PCR.
Positive_regulation (induction) of Runx2 in osteoblast associated with osteoporosis
9) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2822826 Disease Relevance 0.10 Pain Relevance 0
Both PTSCs and ATSCs in osteogenic medium expressed significantly higher levels of Runx2 compared to the same cells in control medium (Figure 3A, B, columns 7 and 8).


Positive_regulation (levels) of Runx2
10) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2822826 Disease Relevance 0.10 Pain Relevance 0
The increased rCBF was found predominantly in the posterior circulation area and visual cortex but some voxels increases in rCBF were found in the anterior circulation.
Positive_regulation (increases) of rCBF in anterior
11) Confidence 0.01 Published 2002 Journal BMC Neurol Section Body Doc Link PMC116601 Disease Relevance 0 Pain Relevance 0
The increased rCBF was found predominantly in the posterior circulation area and visual cortex but some voxels increases in rCBF were found in the anterior circulation.
Positive_regulation (increased) of rCBF in anterior
12) Confidence 0.01 Published 2002 Journal BMC Neurol Section Body Doc Link PMC116601 Disease Relevance 0 Pain Relevance 0
Following acetazolamide at the 20-minute time point, the rCBF in the control group was significantly elevated in a more central and anterior distribution (p = 0.041), while the distribution of the higher rCBF voxels in the Fabry group was more posterior (data not shown, p = 0.002).
Positive_regulation (elevated) of rCBF in posterior
13) Confidence 0.01 Published 2002 Journal BMC Neurol Section Body Doc Link PMC116601 Disease Relevance 0.06 Pain Relevance 0
In view of the normal visual area reactivity in Fabry disease, these findings indicate that the Fabry group response to visual activation is largely explained by the elevated resting rCBF.
Positive_regulation (elevated) of rCBF associated with fabry disease
14) Confidence 0.01 Published 2002 Journal BMC Neurol Section Body Doc Link PMC116601 Disease Relevance 0.52 Pain Relevance 0
At the 30-minute time point the significantly elevated rCBF in the control group had disappeared while the significantly elevated rCBF in the Fabry group persisted (Figure 2, p = 0.003) indicating a prolonged cerebral vascular response time.
Positive_regulation (elevated) of rCBF
15) Confidence 0.01 Published 2002 Journal BMC Neurol Section Body Doc Link PMC116601 Disease Relevance 0.08 Pain Relevance 0
Previously, we demonstrated that the resting rCBF in Fabry disease is elevated compared to controls particularly in the posterior circulation [5].
Positive_regulation (elevated) of rCBF in posterior associated with fabry disease
16) Confidence 0.01 Published 2002 Journal BMC Neurol Section Body Doc Link PMC116601 Disease Relevance 0.42 Pain Relevance 0

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