INT171636

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.92
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLAT) protein modification process (PLAT) extracellular space (PLAT)
extracellular region (PLAT) cytoplasm (PLAT)
Anatomy Link Frequency
plasma 4
forearm 2
endothelial cells 2
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 5 97.08 Very High Very High Very High
cva 13 96.96 Very High Very High Very High
bradykinin 31 94.36 High High
Migraine 76 91.44 High High
anesthesia 1 78.28 Quite High
Inflammation 38 75.00 Quite High
antagonist 13 60.32 Quite High
ischemia 18 54.24 Quite High
substance P 16 11.24 Low Low
cytokine 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 5 97.08 Very High Very High Very High
Stress 56 97.00 Very High Very High Very High
Thrombosis 12 96.96 Very High Very High Very High
Adhesions 43 94.64 High High
Apoptosis 93 93.68 High High
Headache 75 91.44 High High
Hemorrhage 7 89.96 High High
Diabetes Mellitus 94 84.08 Quite High
Increased Venous Pressure Under Development 44 82.52 Quite High
Coronary Artery Disease 22 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used six groups: the control (I/R) (n = 5) group received an intravenous infusion of saline; the second group (tPA, n = 5) was treated with t-PA (human rtPA, Sigma Chemical, St.
Negative_regulation (treated) of Gene_expression (group) of tPA
1) Confidence 0.35 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC117121 Disease Relevance 0.20 Pain Relevance 0.11
PAI-1 represent the most important physiological inhibitor of tissue-type plasminogen activator (TPA) in plasma and elevated levels have been implicated in the pathogenesis of thromboembolic disease (Ridker 1992).
Negative_regulation (inhibitor) of Gene_expression (represent) of tissue-type plasminogen activator in plasma associated with cva
2) Confidence 0.29 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.48 Pain Relevance 0.13
PAI-1 represent the most important physiological inhibitor of tissue-type plasminogen activator (TPA) in plasma and elevated levels have been implicated in the pathogenesis of thromboembolic disease (Ridker 1992).
Negative_regulation (inhibitor) of Gene_expression (represent) of TPA in plasma associated with cva
3) Confidence 0.29 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.48 Pain Relevance 0.13
CSD: cortical spreading depression; ET-1: endothelin-1; FBF: forearm blood flow; FMD: flow-mediated dilation; L-NMMA: NG-monomethyl-L-arginine; NO: nitric oxide; NOS: nitric oxide synthase; SBP: systolic blood pressure; SNP: sodium nitroprusside; t-PA: tissue plasminogen activator

Competing interests

Negative_regulation (pressure) of Gene_expression (synthase) of t-PA in forearm associated with depression
4) Confidence 0.28 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.60 Pain Relevance 0.42
The single strongest effect was observed in tPA marker rs879293 with a significant allelic (p?
Negative_regulation (observed) of Gene_expression (marker) of tPA
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2553267 Disease Relevance 0.43 Pain Relevance 0.15
Additionally, gLDL prevents shear stress-mediated L-arginine uptake and nitric oxide formation and causes increased production of plasminogen-activator inhibitor 1 and prostaglandins, while inhibiting the expression of tissue plasminogen activator in endothelial cells [85–87].
Negative_regulation (inhibiting) of Gene_expression (expression) of tissue plasminogen activator in endothelial cells associated with stress
6) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.73 Pain Relevance 0

General Comments

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