INT171650

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CDK5R1) cytosol (CDK5R1) plasma membrane (CDK5R1)
nucleus (CDK5R1) embryo development (CDK5R1) kinase activity (CDK5R1)
Anatomy Link Frequency
cleavage 1
CDK5R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 11 71.56 Quite High
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 23 85.44 High High
Neuroblastoma 9 80.56 Quite High
Intellectual Impairment 5 76.64 Quite High
Neurodegenerative Disease 11 74.40 Quite High
Nervous System Malformation 9 72.04 Quite High
Disease 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In most cases the quantitative analysis of luciferase mRNA suggests that CDK5R1 3'-UTR affects mRNA stability.
Protein_catabolism (stability) of CDK5R1
1) Confidence 0.63 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC2222623 Disease Relevance 0.30 Pain Relevance 0.04
To investigate the functional impact of the TAP mutations on cathepsin B mediated cleavage of the trypsinogen activating K23-I24 bond, the corresponding peptides pWT, APFDDDDKIVGG; pD22G, APFDDDGKIVGG; and pK23R, APFDDDDRIVGG were digested with cathepsin B for 30 min at pH 3.8 and 5.0, and the fragments were analysed by high-performance liquid chromatography.


Protein_catabolism (cleavage) of pK23R in cleavage
2) Confidence 0.01 Published 2002 Journal BMC Gastroenterol Section Abstract Doc Link PMC117221 Disease Relevance 0.16 Pain Relevance 0

General Comments

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