INT171654

Context Info Confidence 0.18 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB) extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)

Anatomy Link Frequency D22 2 CTSB (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 3 16.40

Disease Link Frequency Relevance Heat Pancreatitis 23 90.56 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

This indicates a high control of cathepsin B action on trypsinogen activation by the amino acid structure of TAP and highlights the particular functional importance of the D22 residue within the tetraaspartic group D19-D20-D21-D22.

Regulation (control) of Regulation (action) of cathepsin B in D22

1) Confidence 0.18 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.18 Pain Relevance 0

General Comments

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