INT171682

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.04
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
neurons 4
plasma 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 181 100.00 Very High Very High Very High
agonist 126 99.98 Very High Very High Very High
Calcium channel 42 99.36 Very High Very High Very High
adenocard 36 97.84 Very High Very High Very High
antagonist 12 78.04 Quite High
Inflammation 11 75.32 Quite High
Central nervous system 10 71.84 Quite High
GABAergic 19 39.84 Quite Low
tolerance 2 23.92 Low Low
ischemia 26 22.08 Low Low
Disease Link Frequency Relevance Heat
Virus Diseases 89 94.80 High High
Prostate Cancer 1 87.52 High High
INFLAMMATION 14 75.32 Quite High
Borna Disease 4 75.00 Quite High
Neurological Disease 4 63.48 Quite High
Targeted Disruption 19 62.96 Quite High
Infection 38 58.76 Quite High
Stress 4 25.12 Quite Low
Disease 13 25.00 Low Low
Cv Unclassified Under Development 26 22.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1-adrenoreceptors) mitoKATP channels are opened via Gi proteins and PKC, possibly PKC-?
Spec (possibly) Positive_regulation (via) of Phosphorylation (opened) of PKC associated with kinase c
1) Confidence 0.43 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.32
1-adrenoreceptors) mitoKATP channels are opened via Gi proteins and PKC, possibly PKC-?
Spec (possibly) Positive_regulation (via) of Phosphorylation (opened) of PKC associated with kinase c
2) Confidence 0.43 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.32
We first showed that the kinetics of dissemination of this recombinant virus was strongly delayed, suggesting that phosphorylation of P by PKC is required for optimal viral spread in neurons.
Positive_regulation (required) of Phosphorylation (phosphorylation) of PKC in neurons associated with kinase c
3) Confidence 0.32 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.89 Pain Relevance 0.48
These authors proposed that the [Ca2+]c rise triggers PKC-dependent Rho-GDI phosphorylation, leading to Rac dissociation of the Rac-Rho-GDI complex and subsequent translocation of Rac to the plasma membrane.
Positive_regulation (triggers) of Phosphorylation (phosphorylation) of PKC-dependent in plasma
4) Confidence 0.18 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.15 Pain Relevance 0.04
agonists leads to an increased calcium influx causing the phosphorylation and activation of PKC.
Positive_regulation (causing) of Phosphorylation (phosphorylation) of PKC associated with kinase c and agonist
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.56
agonists stimulated the phosphorylation of PKC, Raf-1 and AKT.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of PKC associated with kinase c and agonist
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.56
The activation of these pathways in neurons from mES cells is dependent on calcium mobilization from L-type VGCC, because nifedipine blocks the increase in calcium oscillations and the phosphorylation of PKC, Raf-1 and AKT.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of PKC in neurons associated with kinase c and calcium channel
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.43

General Comments

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