INT171683

Context Info Confidence 0.06 First Reported 2002 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.28 Pain Relevance 0.46

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK) cytoplasm (TXK)

Anatomy Link Frequency myocardium 2 TXK (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 41 100.00 antagonist 6 67.24 Pain 2 64.64 adenocard 18 10.84 ischemia 13 5.00 agonist 4 5.00 headache 4 5.00 Inflammation 2 5.00 Taxol 2 5.00 Opioid 2 5.00

Disease Link Frequency Relevance Heat Cancer 84 98.40 Noninfiltrating Intraductal Carcinoma 9 97.48 Breast Cancer 129 94.96 Metastasis 12 91.20 Pain 2 64.64 Toxicity 6 42.92 Disease Progression 3 41.00 Disease 18 39.64 Exanthema 10 34.64 Diarrhoea 10 33.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

in the development of small molecule tyrosine kinase inhibitors (smTKIs) for targeting EGFR in various cancer types

Negative_regulation (development) of Negative_regulation (inhibitors) of tyrosine kinase associated with cancer

1) Confidence 0.06 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.19 Pain Relevance 0

But again, the mechanism of preconditioning the human myocardium may not be applicable to all species as suggested by the need to combine the inhibition of PKC and tyrosine kinase to abort the protection of preconditioning in pigs. [30]

Negative_regulation (combine) of Negative_regulation (inhibition) of tyrosine kinase in myocardium associated with kinase c

2) Confidence 0.06 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.12 Pain Relevance 0.46

These findings indicate that tyrosine kinase inhibitor (TKI) blockade of EGFR has potential in the treatment and chemoprevention of DCIS [47] (Table 1).

Negative_regulation (inhibitor) of Negative_regulation (blockade) of tyrosine kinase associated with noninfiltrating intraductal carcinoma

3) Confidence 0.06 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.97 Pain Relevance 0

General Comments

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