INT171685

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.39
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HSPB1) cell death (HSPB1) plasma membrane (HSPB1)
cytoskeleton (HSPB1) nucleus (HSPB1) intracellular (HSPB1)
Anatomy Link Frequency
nucleus 1
HSPB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 1 95.48 Very High Very High Very High
Kinase C 40 92.96 High High
Osteoarthritis 54 5.00 Very Low Very Low Very Low
adenocard 18 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
ischemia 13 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 4 100.00 Very High Very High Very High
Stress 19 94.16 High High
Adhesions 2 7.20 Low Low
Osteoarthritis 54 5.00 Very Low Very Low Very Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 13 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, some of these proteins, such as heat shock protein beta-1 (HSPB1) or alpha enolase (ENOA) were present in more than one spot, indicating that they undergo posttranslational modifications, such as glycosylation or phosphorylation.
Phosphorylation (phosphorylation) of HSPB1 associated with shock
1) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.10 Pain Relevance 0
Interestingly, some of these proteins, such as heat shock protein beta-1 (HSPB1) or alpha enolase (ENOA) were present in more than one spot, indicating that they undergo posttranslational modifications, such as glycosylation or phosphorylation.
Phosphorylation (phosphorylation) of heat shock protein beta-1 associated with shock
2) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.10 Pain Relevance 0
Thus, for example, the low molecular weight heat shock protein HSP27 may be phosphorylated by p38MAPK via the intermediate MAPKAPK2 [35] and this may lead to polymerization of actin [36] and to increase tolerance of the cytoskeleton to stress. [37] Translocation of PKC isoforms to mitochondrial sites, intercalated discs and nucleus may suggest that p38MAPK activation in these places may activate enzymes involved with energy production, intercellular communication through cell junctions or gene transcriptions.
Phosphorylation (phosphorylated) of HSP27 in nucleus associated with stress, kinase c, shock and tolerance
3) Confidence 0.38 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.19 Pain Relevance 0.24

General Comments

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