INT171690

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Context Info
Confidence 0.55
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.62
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
neurons 1
lung 1
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 299 97.32 Very High Very High Very High
depression 89 87.88 High High
cannabis 11 85.20 High High
Ventral tegmentum 102 82.96 Quite High
Cannabinoid 54 81.28 Quite High
Dopamine 44 78.96 Quite High
anesthesia 6 74.64 Quite High
cytokine 8 58.48 Quite High
Mechanotransduction 2 57.56 Quite High
Electroencephalography 13 41.16 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 273 100.00 Very High Very High Very High
Fistula 42 90.40 High High
Depression 89 87.88 High High
Convulsion 63 87.60 High High
Death 168 85.52 High High
Necrosis 5 82.40 Quite High
Paralysis 2 66.96 Quite High
Li-fraumeni Syndrome 16 63.44 Quite High
Pressure Volume 2 Under Development 70 63.36 Quite High
Stress 45 51.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels were significantly lower at 24 h (Figure 7), most likely due to decreased transcription of caspase-3.
Transcription (transcription) of caspase-3
1) Confidence 0.55 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.31 Pain Relevance 0.36
Caspase-3 activities increased in prenatal rat hippocampal neurons
Transcription (activities) of Caspase-3 in neurons
2) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.27 Pain Relevance 0
However, the addition of caspase-3 specific inhibitor 50 ?
Transcription (addition) of caspase-3
3) Confidence 0.33 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.19 Pain Relevance 0.19
, caspase-3, and PCIII mRNA expressions were measured in lung tissue.
Transcription (expressions) of caspase-3 in lung
4) Confidence 0.11 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 0.35 Pain Relevance 0.07
There was an increase in caspase-3 and Bax mRNA levels at 4 weeks.
Transcription (levels) of caspase-3
5) Confidence 0.11 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.70 Pain Relevance 0.06
There was an increase in caspase-3 and Bax mRNA levels at 4W.
Transcription (levels) of caspase-3
6) Confidence 0.11 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.18 Pain Relevance 0.03
The cooperation of BzATP with NMDA and BDNF was also reproduced at the level of the apoptotic inducer caspase-3.
Transcription (level) of apoptotic inducer caspase-3 associated with apoptosis
7) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.10 Pain Relevance 0
Scrambled peptide exerted no significant effects on the acquisition of CPP (p<0.01 versus pre-test, n?
Transcription (acquisition) of CPP
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.51 Pain Relevance 0.66

General Comments

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