INT171691

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Context Info
Confidence 0.20
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 33
Disease Relevance 11.57
Pain Relevance 6.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
ECM 5
chondrocytes 3
synovial fluid 1
embryo 1
knee joints 1
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 278 99.52 Very High Very High Very High
fibrosis 51 99.46 Very High Very High Very High
Osteoarthritis 722 98.72 Very High Very High Very High
Arthritis 285 97.64 Very High Very High Very High
Inflammation 197 97.44 Very High Very High Very High
chemokine 32 97.44 Very High Very High Very High
ischemia 113 97.40 Very High Very High Very High
induced neuropathy 2 97.16 Very High Very High Very High
cytokine 118 97.00 Very High Very High Very High
Dismenorea 12 93.52 High High
Disease Link Frequency Relevance Heat
Injury 208 99.92 Very High Very High Very High
Cirrhosis 30 99.46 Very High Very High Very High
Osteoarthritis 741 98.72 Very High Very High Very High
Metastasis 6 98.40 Very High Very High Very High
Arthritis 285 97.64 Very High Very High Very High
INFLAMMATION 227 97.44 Very High Very High Very High
Cv Unclassified Under Development 101 97.40 Very High Very High Very High
Neuropathic Pain 2 96.84 Very High Very High Very High
Cancer 46 95.44 Very High Very High Very High
Dysmenorrhea 12 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
silences or decreases the expression of genes related with the systems aforementioned, it also could affect tissue remodelling by directly modifying the proteases involved in this process, or indirectly by affecting the ECM turnover and degradation, important in the accumulation of a spongy mass of tissue around each embryo during decidualization [45].
Protein_catabolism (degradation) of ECM in embryo
1) Confidence 0.20 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
is related to the turnover and degradation of the ECM which provides mechanical strength to the tissue.
Protein_catabolism (degradation) of ECM
2) Confidence 0.20 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.17 Pain Relevance 0.32
Plasmin is able to degrade most of the components of the ECM either directly or indirectly by the activation of MMPs.
Protein_catabolism (degrade) of ECM
3) Confidence 0.17 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.03
Degradation of the extracellular matrix (ECM) is associated with the development of tumor metastasis and tissue growth.
Protein_catabolism (Degradation) of ECM in ECM associated with metastasis
4) Confidence 0.15 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.24 Pain Relevance 0.05
The cell proliferation and differentiation process is also an event involving uPA catalytic ECM degradation that increases cell migration by activating MMP 9 [21].
Protein_catabolism (degradation) of ECM in ECM
5) Confidence 0.15 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.27 Pain Relevance 0.03
Furthermore, urokinase plasminogen activator (uPA) is involved in tissue regeneration. uPA cleaves plasminogen to plasmin to promote extracellular matrix (ECM) degradation for cell proliferation during the recovery from injury [7].
Protein_catabolism (degradation) of ECM in extracellular matrix associated with injury
6) Confidence 0.14 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.17 Pain Relevance 0.07
is directly or indirectly related with the turnover and degradation of the ECM.
Protein_catabolism (degradation) of ECM
7) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.15 Pain Relevance 0.23
can stimulate PAI-1, inhibiting the protease degradation of the ECM.
Protein_catabolism (degradation) of ECM
8) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.06 Pain Relevance 0.12
Genes such as gelatinase A (MMP-2), TIMP2 and 3 [14,15], cathepsin L [16], carboxypeptidase D are included in different groups of proteases, and can directly affect the degradation of the ECM.
Protein_catabolism (degradation) of ECM
9) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.13 Pain Relevance 0.20
It is conceivable that after an acute regulation of cell proliferation and ECM degradation, TGF-?
Protein_catabolism (degradation) of ECM
10) Confidence 0.09 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.28 Pain Relevance 0
FGF8 and IL-1 synergistically accelerated the degradation of the ECM.
Protein_catabolism (degradation) of ECM
11) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.58 Pain Relevance 0.29
A concentration of FGF8 (100 ng/ml) that caused ECM degradation was used.
Protein_catabolism (degradation) of ECM
12) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
FGF8 also induced degradation of the ECM in cultured chondrocytes.
Protein_catabolism (degradation) of ECM in chondrocytes
13) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.67 Pain Relevance 0.20
that showed no effect by itself on ECM degradation was used.
Protein_catabolism (degradation) of ECM
14) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
Degradation of the ECM was promoted in the presence of FGF8.
Protein_catabolism (Degradation) of ECM
15) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.25 Pain Relevance 0.08
MMP-3 is believed to be a key enzyme involved in the degradation of the ECM [4].
Protein_catabolism (degradation) of ECM in ECM
16) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.09 Pain Relevance 0.46
Anti-FGF8 antibody blocked this FGF8 with IL-1-induced degradation of the ECM.
Protein_catabolism (degradation) of ECM
17) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.94 Pain Relevance 0.45
In cultured chondrocytes, degradation of the ECM induced by FGF8 was further enhanced by a small amount of IL-1.
Protein_catabolism (degradation) of ECM in chondrocytes
18) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.79 Pain Relevance 0.38
FGF8 dose-dependently induced ECM degradation.
Protein_catabolism (degradation) of ECM
19) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.07 Pain Relevance 0
This indicated that FGF8 may promote degradation of the ECM by production of proteases including MMP-3.
Protein_catabolism (degradation) of ECM
20) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.17 Pain Relevance 0.13

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