INT171692

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.50
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
embryo 2
ECM 2
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 8 97.84 Very High Very High Very High
ischemia 53 97.40 Very High Very High Very High
cytokine 18 97.40 Very High Very High Very High
induced neuropathy 1 97.16 Very High Very High Very High
metalloproteinase 35 92.80 High High
Inflammatory mediators 1 89.48 High High
Inflammation 22 88.00 High High
Mechanotransduction 1 44.40 Quite Low
Hippocampus 4 25.00 Low Low
Osteoarthritis 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 50 97.40 Very High Very High Very High
Neuropathic Pain 1 96.84 Very High Very High Very High
Wound Healing 1 90.64 High High
Injury 47 90.04 High High
INFLAMMATION 26 89.08 High High
Stress 19 78.88 Quite High
Hypoxia 9 78.88 Quite High
Brain Injury 2 75.00 Quite High
Apoptosis 31 50.00 Quite Low
Fistula 21 16.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
silences or decreases the expression of genes related with the systems aforementioned, it also could affect tissue remodelling by directly modifying the proteases involved in this process, or indirectly by affecting the ECM turnover and degradation, important in the accumulation of a spongy mass of tissue around each embryo during decidualization [45].
Regulation (affecting) of Protein_catabolism (degradation) of ECM in embryo
1) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
that showed no effect by itself on ECM degradation was used.
Neg (no) Regulation (effect) of Protein_catabolism (degradation) of ECM
2) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
It is conceivable that after an acute regulation of cell proliferation and ECM degradation, TGF-?
Regulation (regulation) of Protein_catabolism (degradation) of ECM
3) Confidence 0.04 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.28 Pain Relevance 0
Thus, therapies targeting ECM degradation and progressive neuroinflammation may be beneficial in reducing H-I – induced neuropathy.
Regulation (targeting) of Protein_catabolism (degradation) of ECM in ECM associated with induced neuropathy, ischemia and neuropathic pain
4) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2527306 Disease Relevance 1.21 Pain Relevance 0.65

General Comments

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