INT171693

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Context Info
Confidence 0.09
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.14
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
liver 1
ECM 1
Schwann cells 1
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 40 99.16 Very High Very High Very High
Inflammatory stimuli 1 91.04 High High
Inflammation 3 88.16 High High
Calcium channel 4 84.12 Quite High
Sciatic nerve 9 82.28 Quite High
Dismenorea 2 68.08 Quite High
metalloproteinase 11 66.56 Quite High
Bile 2 65.20 Quite High
cytokine 11 59.88 Quite High
chemokine 4 59.32 Quite High
Disease Link Frequency Relevance Heat
Cirrhosis 27 99.40 Very High Very High Very High
Diastolic Heart Failure 4 98.92 Very High Very High Very High
Myocardial Infarction 5 95.28 Very High Very High Very High
Coronary Heart Disease 18 94.00 High High
Hypertrophy 12 91.60 High High
INFLAMMATION 5 90.72 High High
Necrosis 4 87.48 High High
Fibrosis 23 85.80 High High
Liver Disease 1 85.76 High High
Injury 19 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is a key factor that favours accumulation of collagen, laminin and fibronectin in the ECM [17].
Positive_regulation (accumulation) of ECM
1) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.13
In addition, zymography showed that the enzyme activity of extracellular matrix regulating protein (MMP 9) and the migration of Schwann cells were increased after danshen and tanshinone IIA treatment.
Positive_regulation (activity) of extracellular matrix regulating protein in Schwann cells
2) Confidence 0.09 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.30 Pain Relevance 0.04
Activated HSCs have been identified as the primary source of excess ECM components in liver fibrosis [4,18].
Positive_regulation (excess) of ECM in liver associated with fibrosis and cirrhosis
3) Confidence 0.05 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2981719 Disease Relevance 0.90 Pain Relevance 0.28
ECM proteins were also upregulated in our study.
Positive_regulation (upregulated) of ECM
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.87 Pain Relevance 0.07
These observations indicate that cell proliferation and ECM accumulation are critically involved in vessel remodeling.
Positive_regulation (accumulation) of ECM in ECM
5) Confidence 0.04 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0 Pain Relevance 0.03

General Comments

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