INT171712

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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 6.57
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (FAT1) plasma membrane (FAT1) nucleus (FAT1)
cell-cell signaling (FAT1) cytoplasm (FAT1)
Anatomy Link Frequency
fat 19
body 1
FAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 90 97.76 Very High Very High Very High
Restless leg syndrome 14 85.52 High High
halothane 34 50.00 Quite Low
antagonist 14 38.16 Quite Low
Catecholamine 196 5.00 Very Low Very Low Very Low
adenocard 14 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 136 99.56 Very High Very High Very High
Diabetes Mellitus 272 99.36 Very High Very High Very High
Overweight 204 99.10 Very High Very High Very High
Body Weight 86 98.64 Very High Very High Very High
Impaired Glucose Tolerance 116 97.76 Very High Very High Very High
Obesity 150 96.48 Very High Very High Very High
Appetite Loss 98 95.36 Very High Very High Very High
Increased Venous Pressure Under Development 16 85.52 High High
Frailty 22 83.96 Quite High
Pulmonary Disease 16 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exactly the same set of parameters were used except that: 1) the fraction of body fat was reduced to 0.16, the standard literature average value [36] for the 12 young male subjects used in this study; and 2) the experimental inhaled enflurane concentration was 0.0186 % for 30 minutes (versus 0.518% for 120 minutes for Carpenter et al).
Negative_regulation (reduced) of fat in fat
1) Confidence 0.15 Published 2002 Journal BMC Anesthesiol Section Body Doc Link PMC122062 Disease Relevance 0 Pain Relevance 0
Body fat decreased over time in both groups but the experimental group lost significantly more body fat (6.3%, p < 0.05) compared to the placebo group (1.9%) (Table 1).
Negative_regulation (lost) of fat in fat
2) Confidence 0.14 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 0.35 Pain Relevance 0
Body fat decreased over time in both groups but the experimental group lost significantly more body fat (6.3%, p < 0.05) compared to the placebo group (1.9%) (Table 1).
Negative_regulation (decreased) of fat in fat
3) Confidence 0.14 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 0.37 Pain Relevance 0
The SOmaxP cohort experienced an increase in strength and a concomitant increase in lean muscle mass and loss in body fat, without a significant change in body weight.
Negative_regulation (loss) of fat in body associated with body weight
4) Confidence 0.09 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0.31 Pain Relevance 0
This review summarizes the results of HIIE studies on fat loss, fitness, insulin resistance, and skeletal muscle.
Negative_regulation (loss) of fat in fat associated with insulin resistance
5) Confidence 0.06 Published 2011 Journal Journal of Obesity Section Abstract Doc Link PMC2991639 Disease Relevance 0.29 Pain Relevance 0.05
Thus, it is feasible that HIIE fat loss programs are effective for producing a clinical decrease in fat (greater than 6% of fat mass) for some but not all participants.
Negative_regulation (decrease) of fat in fat
6) Confidence 0.06 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.11 Pain Relevance 0.03
Studies using overweight male and female type 2 diabetic individuals have shown greater reductions in subcutaneous and abdominal fat.
Negative_regulation (reductions) of fat in fat associated with diabetes mellitus and overweight
7) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.56 Pain Relevance 0
For example, Tremblay et al. [38] compared HIIE and steady state aerobic exercise and found that after 24 weeks subjects in the HIIE group lost more subcutaneous fat, as measured by skin folds, compared to a steady state exercise group when exercise volume was taken into account (Table 1).
Negative_regulation (lost) of fat in fat
8) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.13 Pain Relevance 0
For example, emerging research examining high-intensity intermittent exercise (HIIE) indicates that it may be more effective at reducing subcutaneous and abdominal body fat than other types of exercise.
Negative_regulation (reducing) of fat in fat
9) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Abstract Doc Link PMC2991639 Disease Relevance 0.21 Pain Relevance 0.03
A small number of studies have examined the effects of HIIE fat loss and health of special populations and patients.
Spec (examined) Negative_regulation (loss) of fat in fat
10) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.35 Pain Relevance 0.09
Thus, exercise protocols that can be carried out by overweight, inactive individuals that more effectively reduce body fat are required.
Negative_regulation (reduce) of fat in fat associated with overweight
11) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.36 Pain Relevance 0
As there are likely to be responders and nonresponders in every exercise, fat loss trial calculating mean fat loss alone hides the significant fat loss achieved by some individuals.
Negative_regulation (loss) of fat in fat
12) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.11 Pain Relevance 0.03
Studies that used longer duration HIIE protocols with individuals possessing moderate elevations in fat mass [5] have resulted in greater weight/fat reduction.
Negative_regulation (reduction) of fat in fat
13) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.71 Pain Relevance 0
Interestingly, the greatest HIIE-induced fat loss was found in two studies that used overweight type 2 diabetic adults (BMI > 29?
Negative_regulation (loss) of fat in fat associated with diabetes mellitus and overweight
14) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.68 Pain Relevance 0
kg decrease in abdominal fat.
Negative_regulation (decrease) of fat in fat
15) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.16 Pain Relevance 0
kg reduction in subcutaneous fat (8%) and a 36% increase in insulin sensitivity (Table 1).
Negative_regulation (reduction) of fat in fat
16) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.10 Pain Relevance 0
Given that greater fat loss to exercise interventions has been found for those individuals possessing larger initial fat mass [54], it is feasible that HIIE will have a greater fat reduction effect on the overweight or obese.
Negative_regulation (loss) of fat in fat associated with obesity and overweight
17) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.62 Pain Relevance 0
Introduction

Most exercise protocols designed to induce fat loss have focused on regular steady state exercise such as walking and jogging at a moderate intensity.

Negative_regulation (loss) of fat in fat
18) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.32 Pain Relevance 0
Resistance training reduces abdominal fat, including visceral fat, among individuals with diabetes [116, 128, 129].
Negative_regulation (reduces) of fat in fat associated with diabetes mellitus
19) Confidence 0.04 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.38 Pain Relevance 0
Resistance training reduces abdominal fat, including visceral fat, among individuals with diabetes [116, 128, 129].
Negative_regulation (reduces) of fat in fat associated with diabetes mellitus
20) Confidence 0.03 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.44 Pain Relevance 0

General Comments

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