INT171739

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Context Info
Confidence 0.25
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.64
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL27) extracellular region (CCL27) cell-cell signaling (CCL27)
Anatomy Link Frequency
skin 2
memory T cell 2
CCL27 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 100.00 Very High Very High Very High
Inflammation 19 95.32 Very High Very High Very High
Inflammatory response 2 93.84 High High
corticosteroid 1 85.12 High High
psoriasis 47 75.16 Quite High
Infliximab 108 50.00 Quite Low
Inflammatory marker 2 50.00 Quite Low
rheumatoid arthritis 10 47.44 Quite Low
Arthritis 5 9.68 Low Low
chemokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 95.32 Very High Very High Very High
Contact Dermatitis 28 89.64 High High
Adhesions 6 87.00 High High
Disease 15 79.72 Quite High
Apoptosis 4 75.52 Quite High
Psoriasis 50 75.16 Quite High
Necrosis 2 63.60 Quite High
Cancer 3 63.24 Quite High
Rheumatoid Arthritis 10 47.44 Quite Low
Hypersensitivity 13 41.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Positive_regulation (elevated) of Gene_expression (expression) of CCL27 in skin associated with inflammation
1) Confidence 0.25 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.73 Pain Relevance 0.22
further stimulates lymphocyte migration, increasing the expression of many proinflammatory cytokines including CCL27 (a skin-specific memory T cell attractant) and NF-kB (a ubiquitous transcription factor) that leads to the expression of many gene products that mediate inflammatory responses (Banno et al 2004).
Positive_regulation (increasing) of Gene_expression (expression) of CCL27 in memory T cell associated with inflammatory response and cytokine
2) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727775 Disease Relevance 0.90 Pain Relevance 0.35

General Comments

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