INT171740

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.71
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL27) extracellular region (CCL27) cell-cell signaling (CCL27)
Anatomy Link Frequency
skin 2
memory T cell 1
CCL27 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 100.00 Very High Very High Very High
chemokine 20 99.52 Very High Very High Very High
Inflammation 29 95.32 Very High Very High Very High
Inflammatory response 3 93.84 High High
corticosteroid 2 84.76 Quite High
psoriasis 47 74.56 Quite High
rheumatoid arthritis 13 73.32 Quite High
Infliximab 108 50.00 Quite Low
Inflammatory marker 4 50.00 Quite Low
antagonist 7 42.48 Quite Low
Disease Link Frequency Relevance Heat
Dermatitis 8 98.20 Very High Very High Very High
INFLAMMATION 34 95.32 Very High Very High Very High
Contact Dermatitis 56 95.28 Very High Very High Very High
Adhesions 10 87.08 High High
Disease 18 79.36 Quite High
Apoptosis 5 75.16 Quite High
Psoriasis 50 74.56 Quite High
Rheumatoid Arthritis 13 73.32 Quite High
Increased Venous Pressure Under Development 3 68.00 Quite High
Necrosis 2 63.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Gene_expression (expression) of CCL27 in skin associated with inflammation
1) Confidence 0.38 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.73 Pain Relevance 0.22
This chemokine may work together with CCL27 and MCP-1/CCL2 which are also produced by activated keratinocytes [30], and may subsequently attract the adherent cells into the epidermis of patients with ACD.
Gene_expression (produced) of CCL27 in epidermis associated with chemokine and contact dermatitis
2) Confidence 0.30 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 1.09 Pain Relevance 0.15
further stimulates lymphocyte migration, increasing the expression of many proinflammatory cytokines including CCL27 (a skin-specific memory T cell attractant) and NF-kB (a ubiquitous transcription factor) that leads to the expression of many gene products that mediate inflammatory responses (Banno et al 2004).
Gene_expression (expression) of CCL27 in memory T cell associated with inflammatory response and cytokine
3) Confidence 0.12 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727775 Disease Relevance 0.90 Pain Relevance 0.34

General Comments

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