INT171742

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 12.26
Pain Relevance 7.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CXCR3) plasma membrane (CXCR3) cytoplasm (CXCR3)
signal transducer activity (CXCR3)
Anatomy Link Frequency
B cells 7
T cells 3
blood 2
endothelial cells 1
cerebrospinal fluid 1
CXCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1149 100.00 Very High Very High Very High
Inflammation 304 99.84 Very High Very High Very High
Multiple sclerosis 12 99.74 Very High Very High Very High
cytokine 106 99.16 Very High Very High Very High
rheumatoid arthritis 822 98.92 Very High Very High Very High
Arthritis 182 98.62 Very High Very High Very High
Osteoarthritis 231 89.12 High High
cINOD 37 87.96 High High
Adalimumab 12 82.28 Quite High
Etanercept 12 81.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 321 99.84 Very High Very High Very High
Demyelinating Disease 12 99.74 Very High Very High Very High
Systemic Lupus Erythematosus 468 99.70 Very High Very High Very High
Contact Dermatitis 28 99.38 Very High Very High Very High
Rheumatoid Arthritis 822 98.92 Very High Very High Very High
Juvenile Chronic Polyarthritis 40 98.62 Very High Very High Very High
Immunization 15 95.84 Very High Very High Very High
Malignant Neoplastic Disease 24 94.16 High High
Osteoarthritis 243 89.12 High High
Disease 124 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analysis of blood samples from patients with RA – and also from some patients with SLE – revealed an increase in the fraction CXCR3-high-expressing (CXCR3hi) B cells (Fig. 6).
Positive_regulation (increase) of CXCR3hi in B cells associated with rheumatoid arthritis and systemic lupus erythematosus
1) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.93 Pain Relevance 0.40
The analysis of blood samples from patients with RA – and also from some patients with SLE – revealed an increase in the fraction CXCR3-high-expressing (CXCR3hi) B cells (Fig. 6).
Positive_regulation (increase) of CXCR3 in B cells associated with rheumatoid arthritis and systemic lupus erythematosus
2) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.93 Pain Relevance 0.40
The downregulation of CXCR5 correlated with an upregulation of CXCR3.
Positive_regulation (upregulation) of CXCR3
3) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 1.02 Pain Relevance 0.59
In our kinetic study over a 48 hours course of provoked human allergic contact dermatitis we found a gradual and higher accumulation of CXCR3+ than CCR5+ cells which was directly associated with CD3+ T cells.
Positive_regulation (accumulation) of CXCR3 in T cells associated with contact dermatitis
4) Confidence 0.43 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.77 Pain Relevance 0.34
We found that in healthy individuals most B cells are positive for CXCR3; however, the mean fluorescence intensity was rather low and only a few B cells expressed CXCR3, at a level comparable to that seen after staining with mAb specific for CXCR5 (Figs 1 and 7).
Positive_regulation (positive) of CXCR3 in B cells
5) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.83 Pain Relevance 0.45
Further experiments will be required to show whether the significant upregulation of CXCR3 on peripheral blood B cells supports their accumulation in the inflamed synovial tissue.
Spec (whether) Positive_regulation (upregulation) of CXCR3 in B cells
6) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.37 Pain Relevance 0.39
The cytometric analysis of healthy controls showed that 93.9% of the B cells were positive for CXCR3, 81.6% for CXCR4, 97.6% for CXCR5, 76.7% for CCR6 and 94.3% for CCR7.
Positive_regulation (positive) of CXCR3 in B cells
7) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.44 Pain Relevance 0.44
In comparison with healthy individuals, in patients with RA a significant fraction of B cells showed a decreased expression of CXCR5 and CCR6 and increased levels of CXCR3.
Positive_regulation (increased) of CXCR3 in B cells associated with rheumatoid arthritis
8) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 1.04 Pain Relevance 0.59
The analysis of patients with multiple sclerosis showed that CXCR3 becomes upregulated on infiltration of the inflamed cerebrospinal fluid [20].
Positive_regulation (upregulated) of CXCR3 in cerebrospinal fluid associated with multiple sclerosis
9) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 1.14 Pain Relevance 0.75
A great variation in chemokine receptor expression was obtained when B cells were tested for CXCR3, which is a receptor for chemokines that is upregulated in inflammation.
Positive_regulation (upregulated) of CXCR3 in B cells associated with chemokine and inflammation
10) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.90 Pain Relevance 0.46
The analysis of chemokine receptor expression showed that the majority of peripheral blood B cells is positive for CXCR3, CXCR4, CXCR5, CCR6 and CCR7.
Positive_regulation (positive) of CXCR3 in blood associated with chemokine
11) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 0.97 Pain Relevance 0.51
Lower levels of chemokine receptor CXCR5 and higher levels of CXCR3 on peripheral blood B cells may represent a generalized change in the profile and might be seen on all of the activated B cells in the systemic compartment or these changes in chemokine receptor expression might serve in selective recruitment into the inflamed tissue.
Positive_regulation (levels) of CXCR3 in blood associated with chemokine
12) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.60 Pain Relevance 0.35
Most strikingly, an increase in the percentage of CXCR3hi naive B cells, a finding characteristic for patients with RA, was observed.
Positive_regulation (increase) of CXCR3hi in naive B cells associated with rheumatoid arthritis
13) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.90 Pain Relevance 0.85
Activation of CXCR3 has also been associated with the ERK1/2 and protein kinase B/Akt signalling pathways, although these pathways are not required for actin polymerisation and chemotaxis [39].
Positive_regulation (Activation) of CXCR3
14) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.08 Pain Relevance 0.10
In endothelial cells and fibroblasts, however, most other cytokine combinations have not been evaluated for induction of CXCR3 ligands [17].
Positive_regulation (induction) of CXCR3 in fibroblasts associated with cytokine
15) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.22 Pain Relevance 0.28
We have previously shown that inflammatory T cells in the joint in JIA are predominantly of an activated memory phenotype and express high levels of the chemokine receptors CCR5 and CXCR3, and that this correlates with the highly Th-1 skewed phenotype of synovial T cells, which make high levels of IFN?
Positive_regulation (levels) of CXCR3 in T cells associated with chemokine, inflammation and arthritis
16) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.65 Pain Relevance 0.50
Since CXCR3 also is induced early in CD4 T lymphocyte differentiation [76], the literature suggests an enhancing role for CXCL10 in both the expression and induction of Th1 immune responses.
Positive_regulation (induced) of CXCR3 in T lymphocyte
17) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.25 Pain Relevance 0.04
In endothelial cells and fibroblasts, however, most other cytokine combinations have not been evaluated for induction of CXCR3 ligands [17].
Positive_regulation (induction) of CXCR3 in endothelial cells associated with cytokine
18) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.22 Pain Relevance 0.28

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