INT171744

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.06
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR4) signal transducer activity (CCR4)
Anatomy Link Frequency
Th2 cells 1
mononuclear cells 1
CCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 98.14 Very High Very High Very High
cytokine 7 96.72 Very High Very High Very High
chemokine 21 93.44 High High
Inflammatory response 1 89.64 High High
antagonist 2 83.84 Quite High
Multiple sclerosis 8 51.84 Quite High
Inflammatory marker 2 50.00 Quite Low
rheumatoid arthritis 3 26.20 Quite Low
tolerance 3 5.00 Very Low Very Low Very Low
intrathecal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 15 98.14 Very High Very High Very High
Transverse Myelitis 3 96.96 Very High Very High Very High
Dermatitis 4 78.36 Quite High
Contact Dermatitis 28 76.64 Quite High
Neurological Disease 13 52.88 Quite High
Hypersensitivity 11 52.88 Quite High
Multiple Sclerosis 10 51.84 Quite High
Disease 5 49.84 Quite Low
Adhesions 14 39.96 Quite Low
Rheumatoid Arthritis 3 26.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using real-time rt-PCR, we were able to verify that CSF mononuclear cells expressed CCR4 mRNA at slightly higher levels compared to PBMCs from the same individual (data not shown).
Transcription (expressed) of CCR4 in mononuclear cells
1) Confidence 0.36 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.20 Pain Relevance 0.10
T lymphocytes with polarized cytokine production (Th1 and Th2) show a different distribution of inflammatory CR, with CXCR3 and CCR5 transcripts markedly enhanced in Th1 cells and increased amounts of transcripts for CCR3, CCR4 and CCR8 in Th2 cells [39].
Transcription (transcripts) of CCR4 in Th2 cells associated with inflammation and cytokine
2) Confidence 0.20 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.85 Pain Relevance 0.37

General Comments

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