INT171746

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CCR8) plasma membrane (CCR8) signal transducer activity (CCR8)
Anatomy Link Frequency
Blood 1
Th1 cells 1
regulatory T cells 1
CCR8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 77 99.58 Very High Very High Very High
Inflammation 72 82.04 Quite High
cytokine 53 79.16 Quite High
antagonist 3 59.60 Quite High
Inflammatory marker 2 50.00 Quite Low
Arthritis 21 5.00 Very Low Very Low Very Low
rheumatoid arthritis 19 5.00 Very Low Very Low Very Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 12 95.92 Very High Very High Very High
Adenocarcinoma 90 92.76 High High
INFLAMMATION 74 82.40 Quite High
Apoptosis 3 79.08 Quite High
Pancreatic Cancer 5 76.96 Quite High
Necrosis 2 68.20 Quite High
Cancer 38 67.84 Quite High
Infection 3 67.80 Quite High
Contact Dermatitis 28 67.24 Quite High
Dermatitis 4 57.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They have a broad array of functional T1- and T2-associated chemokine receptors, but also express high levels of CCR2 and CCR8 which allow resting as well as activated Th IL-10 cells to display a significant migratory capacity to CCL2 and CCL1 [46].


Gene_expression (express) of CCR8 associated with chemokine
1) Confidence 0.40 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.36 Pain Relevance 0.21
Blood PDCs express many different chemokine receptors including CCR2, CCR5, CCR6, CCR7, CXCR3, and CXCR4 [40], whereas MDC express CCR1, CCR2, CCR3, CCR5, CCR6, CCR7 and CCR8 [19], [20], [21].
Gene_expression (express) of CCR8 in Blood associated with chemokine
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.23 Pain Relevance 0.15
The majority of CD4+CD25high regulatory T cells express CCR4 and CCR8 [59], but other chemokine receptors and integrin molecules, such CD103, are also present.
Gene_expression (express) of CCR8 in regulatory T cells associated with chemokine
3) Confidence 0.27 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.29 Pain Relevance 0.22
Th1 cells preferentially express CCR5, CXCR3, and CXCR6, whereas Th2 cells preferentially express CCR4 and CCR8.
Gene_expression (express) of CCR8 in Th1 cells
4) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.41 Pain Relevance 0.31

General Comments

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