INT171749

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 11.03
Pain Relevance 6.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CXCR3) plasma membrane (CXCR3) cytoplasm (CXCR3)
signal transducer activity (CXCR3)
Anatomy Link Frequency
B cells 12
plasma cells 3
fibroblasts 3
memory B cells 3
leukocytes 3
CXCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1133 100.00 Very High Very High Very High
Inflammation 363 100.00 Very High Very High Very High
cytokine 150 99.90 Very High Very High Very High
rheumatoid arthritis 847 98.92 Very High Very High Very High
Osteoarthritis 232 90.96 High High
cINOD 37 88.60 High High
Inflammatory response 9 74.64 Quite High
metalloproteinase 10 72.48 Quite High
Adalimumab 12 61.20 Quite High
Etanercept 12 60.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 386 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 468 99.70 Very High Very High Very High
Rheumatoid Arthritis 855 98.92 Very High Very High Very High
Injury 4 94.92 High High
Disease 148 94.76 High High
Atherosclerosis 204 91.40 High High
Osteoarthritis 244 90.96 High High
Malignant Neoplastic Disease 24 90.32 High High
Necrosis 42 88.72 High High
Cancer 40 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, it was shown for T lymphocytes that after activation with interleukin-2 the expression of CXCR3 is upregulated [32].
Positive_regulation (upregulated) of Gene_expression (expression) of CXCR3 in T lymphocytes
1) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.39 Pain Relevance 0.28
Using a transmigration assay we were able to show that low levels of CXCR3 expression are sufficient to permit a response to the migrational stimulus of the chemokine CXCL10.
Positive_regulation (sufficient) of Gene_expression (expression) of CXCR3 associated with chemokine
2) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.48 Pain Relevance 0.34
In comparison with healthy individuals, in patients with RA a significant fraction of B cells showed a decreased expression of CXCR5 and CCR6 and increased levels of CXCR3.
Positive_regulation (increased) of Gene_expression (levels) of CXCR3 in B cells associated with rheumatoid arthritis
3) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 1.04 Pain Relevance 0.59
Activation of human B cells using a culture system in vitro showed that after stimulation with cytokines the expression of CXCR3 is upregulated [31].
Positive_regulation (upregulated) of Gene_expression (expression) of CXCR3 in B cells associated with cytokine
4) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.45 Pain Relevance 0.28
There was therefore no evidence that CXCR3 expression is preferentially enhanced on CD5+ B cells.


Positive_regulation (enhanced) of Gene_expression (expression) of CXCR3 in B cells
5) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.45 Pain Relevance 0.31
The analysis of blood samples from patients with RA – and also from some patients with SLE – revealed an increase in the fraction CXCR3-high-expressing (CXCR3hi) B cells (Fig. 6).
Positive_regulation (increase) of Gene_expression (expressing) of CXCR3hi in B cells associated with rheumatoid arthritis and systemic lupus erythematosus
6) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.93 Pain Relevance 0.40
The results obtained for CXCR3 suggest that its expression is upregulated as B cells differentiate into memory B cells and plasma cells.
Positive_regulation (upregulated) of Gene_expression (expression) of CXCR3 in plasma cells
7) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.95 Pain Relevance 0.41
The analysis of blood samples from patients with RA – and also from some patients with SLE – revealed an increase in the fraction CXCR3-high-expressing (CXCR3hi) B cells (Fig. 6).
Positive_regulation (increase) of Gene_expression (expressing) of CXCR3 in B cells associated with rheumatoid arthritis and systemic lupus erythematosus
8) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.93 Pain Relevance 0.40
To test whether low expression of CXCR3 on B cells is sufficient to respond to the inflammatory chemokine CXCL10, PBMC from patients with RA were tested with the use of a transmigration assay (Fig. 11).
Spec (whether) Positive_regulation (sufficient) of Gene_expression (expression) of CXCR3 in B cells associated with chemokine, inflammation and rheumatoid arthritis
9) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.79 Pain Relevance 0.80
After differentiation, the level of CXCR3 expression seems to be upregulated because the frequency of CXCR3hi B cells increases from naive to memory B cells.
Positive_regulation (upregulated) of Gene_expression (expression) of CXCR3 in memory B cells
10) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.32 Pain Relevance 0.24
In contrast, the expression of CXCR3, a receptor reactive to inflammatory chemokines [4,10], was increased.
Positive_regulation (increased) of Gene_expression (expression) of CXCR3 associated with chemokine and inflammation
11) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 1.20 Pain Relevance 0.76
The Chinese hamster ovary (CHO) cell line transfected with CXCR3 was cultured in Ham's F-12 growth medium (Cambrex Bio Science) enriched with 10% FBS (Invitrogen), 400 ?
Positive_regulation (transfected) of Gene_expression (transfected) of CXCR3 in ovary
12) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.19 Pain Relevance 0.07
upregulates the expression of CXCR3 promoting the development of the Th1 lymphocyte ()pathway which is strongly proinflammatory.
Positive_regulation (upregulates) of Gene_expression (expression) of CXCR3 in lymphocyte
13) Confidence 0.38 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.59 Pain Relevance 0.26
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Positive_regulation (incubated) of Gene_expression (one) of CXCR3 in 1C6
14) Confidence 0.31 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.08
CXCR3 expression was significantly increased on synovial fluid CD4+ T cells as compared with peripheral blood CD4+ T cells (P = 0.006).


Positive_regulation (increased) of Gene_expression (expression) of CXCR3 in synovial fluid
15) Confidence 0.30 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193728 Disease Relevance 0 Pain Relevance 0.05
-induced CXCR3 ligand production in peripheral blood mononuclear cells [11,12].
Positive_regulation (induced) of Gene_expression (production) of CXCR3 in mononuclear cells
16) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.22 Pain Relevance 0.24
(MIG), resulting in enhanced recruitment of CXCR3+ leukocytes and haematopoietic progenitor cells.
Positive_regulation (enhanced) of Gene_expression (leukocytes) of CXCR3 in leukocytes
17) Confidence 0.27 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.67 Pain Relevance 0.17
In addition, some Toll-like receptor ligands (e.g. double-stranded RNA) stimulate the production of these CXCR3 ligands in leukocytes and fibroblasts [11,12].
Positive_regulation (stimulate) of Gene_expression (production) of CXCR3 in fibroblasts
18) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.23 Pain Relevance 0.21
The results obtained for CXCR3 suggest that its expression is upregulated as B cells differentiate into memory B cells and plasma cells.
Positive_regulation (upregulated) of in memory B cells Gene_expression (expression) of CXCR3 in plasma cells
19) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.95 Pain Relevance 0.41
In addition, some Toll-like receptor ligands (e.g. double-stranded RNA) stimulate the production of these CXCR3 ligands in leukocytes and fibroblasts [11,12].
Positive_regulation (stimulate) of in leukocytes Gene_expression (production) of CXCR3 in fibroblasts
20) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.23 Pain Relevance 0.21

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