INT171750

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.38
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL13) extracellular space (CCL13) extracellular region (CCL13)
cytoskeleton organization (CCL13) cell-cell signaling (CCL13)
Anatomy Link Frequency
skin 4
gray matter 2
CCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 67 97.52 Very High Very High Very High
Multiple sclerosis 60 90.72 High High
corticosteroid 4 85.12 High High
chemokine 98 72.00 Quite High
Central nervous system 50 68.16 Quite High
cytokine 21 65.08 Quite High
rheumatoid arthritis 6 51.84 Quite High
Inflammatory marker 4 50.00 Quite Low
antagonist 12 5.00 Very Low Very Low Very Low
Demyelination 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 71 97.52 Very High Very High Very High
Neurological Disease 12 97.48 Very High Very High Very High
Encephalitis 2 95.48 Very High Very High Very High
Alzheimer's Dementia 1 94.40 High High
Parkinson's Disease 1 93.44 High High
Demyelinating Disease 78 90.72 High High
Contact Dermatitis 56 89.64 High High
Disease 25 79.72 Quite High
Apoptosis 5 75.52 Quite High
Central Nervous System Disease 48 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Positive_regulation (elevated) of Gene_expression (expression) of CCL13 in skin associated with inflammation
1) Confidence 0.33 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.79 Pain Relevance 0.24
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Positive_regulation (elevated) of Gene_expression (expression) of MCP-4 in skin associated with inflammation
2) Confidence 0.33 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.79 Pain Relevance 0.24
In consensus with others, however, we also note an increased CCL7, CCL8 and CCL13 expression in the white matter as compared to the gray matter in 5 other neurological disease controls (1 viral and 1 post-infectious encephalitis, 2 Alzheimer disease and 1 Parkinson disease).
Positive_regulation (increased) of Gene_expression (expression) of CCL13 in gray matter associated with parkinson's disease, neurological disease, alzheimer's dementia and encephalitis
3) Confidence 0.13 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.80 Pain Relevance 0.25

General Comments

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