INT171765

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 7.64
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP15) protein modification process (MMP15)
Anatomy Link Frequency
connective tissue 1
lung 1
MMP15 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 13 99.60 Very High Very High Very High
cytokine 10 96.52 Very High Very High Very High
Inflammatory mediators 2 95.96 Very High Very High Very High
Inflammation 49 75.92 Quite High
metalloproteinase 144 55.96 Quite High
rheumatoid arthritis 21 5.00 Very Low Very Low Very Low
Multiple sclerosis 12 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
psoriasis 8 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 18 99.84 Very High Very High Very High
Glioma 6 99.84 Very High Very High Very High
Metastasis 27 99.68 Very High Very High Very High
Syndrome 56 99.64 Very High Very High Very High
Pancreatic Cancer 3 99.08 Very High Very High Very High
Lung Cancer 3 98.76 Very High Very High Very High
Cancer 120 98.68 Very High Very High Very High
Skin Cancer 15 97.28 Very High Very High Very High
Colon Cancer 12 96.08 Very High Very High Very High
INFLAMMATION 51 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A hypothetical role for MMP2 and MMP15 in the Blau syndrome is that aberrant expression of MMP2 and MMP15 could inappropriately degrade connective tissue, which, in turn, could release stored cytokines and inflammatory mediators, such as tumor necrosis factor ?
Gene_expression (expression) of MMP15 in connective tissue associated with necrosis, inflammatory mediators, cancer, syndrome and cytokine
1) Confidence 0.59 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.62 Pain Relevance 0.17
Four genes, namely, CES1, MMP2, MMP15, and SCYA17, were selected based on their biochemical function and physical map locations prior to completion of our high-resolution map.
Gene_expression (selected) of MMP15
2) Confidence 0.46 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0 Pain Relevance 0
MMP-15 mRNA is expressed in breast carcinoma [112] and pancreatic cancer tissues [113].
Gene_expression (expressed) of MMP-15 mRNA associated with pancreatic cancer and breast cancer
3) Confidence 0.27 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 2.29 Pain Relevance 0.07
Chemokine CXCL12 upregulates MMP-15 expression in glioma cells and serves as an effector of CXCR4 signaling in these cells by promoting cell invasion [46].
Gene_expression (expression) of MMP-15 associated with chemokine and glioma
4) Confidence 0.24 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 2.42 Pain Relevance 0.05
Higher levels of MMP-15 are observed in nonsmall cell lung carcinomas (NSCLCs) relative to squamous cell carcinoma (SCCs) and normal lung tissues which indicate that MMP-15 may be a viable molecular diagnostic marker for NSCLCs [96].
Gene_expression (levels) of MMP-15 in lung associated with lung cancer and skin cancer
5) Confidence 0.21 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 2.31 Pain Relevance 0.07

General Comments

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