INT171772

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.92
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CPB1) extracellular region (CPB1)
Anatomy Link Frequency
brain 1
heart 1
CPB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 25 99.98 Very High Very High Very High
Inflammation 29 99.82 Very High Very High Very High
cytokine 16 99.10 Very High Very High Very High
cva 16 98.70 Very High Very High Very High
ischemia 6 97.68 Very High Very High Very High
imagery 41 86.64 High High
depression 1 80.48 Quite High
Central nervous system 2 66.96 Quite High
Inflammatory mediators 6 50.00 Quite Low
Analgesic 1 47.12 Quite Low
Disease Link Frequency Relevance Heat
Injury 116 99.98 Very High Very High Very High
INFLAMMATION 62 99.82 Very High Very High Very High
Acute Renal Failure 16 99.80 Very High Very High Very High
Obesity 16 99.76 Very High Very High Very High
Pressure And Volume Under Development 55 99.44 Very High Very High Very High
Cancer 5 99.36 Very High Very High Very High
Necrosis 6 98.88 Very High Very High Very High
Cv General 3 Under Development 28 98.70 Very High Very High Very High
Coronary Artery Disease 12 97.68 Very High Very High Very High
Phobia 42 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the report from Légaré et Al [11], in which two groups of patients undergoing CABG with CPB or on the beating heart are compared, does not demonstrate any difference between the two groups, with regards to postoperative mortality, morbidity and hospital stay length.
CPB Binding (undergoing) of in heart
1) Confidence 0.32 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2474599 Disease Relevance 0.56 Pain Relevance 0
However, one can hypothesize that postoperative anxiety disorders including claustrophobia may be a manifestation of mild neurological impairment secondary to embolism, brain hypoperfusion, cerebral edema, and inflammatory response associated with CPB.
CPB Binding (associated) of in brain associated with phobia, pressure and volume under development, inflammatory response, anxiety disorder and cva
2) Confidence 0.29 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518378 Disease Relevance 1.78 Pain Relevance 0.24
Four patients had their operations converted to CPB; three for unstable haemodynamics and one for myocardial optimisation following a myocardial infarction intra-operatively.
CPB Binding (operations) of associated with myocardial infarction
3) Confidence 0.28 Published 2008 Journal Ulster Med J Section Body Doc Link PMC2516433 Disease Relevance 0.68 Pain Relevance 0.11
The aim of this prospective study was to investigate the level of troponin-I release in both off-pump and CPB-technique CABG surgery, and determine whether there is a significant myocardial injury associated with CPB, as suggested by the literature.
CPB Binding (associated) of associated with injury
4) Confidence 0.27 Published 2006 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2323524 Disease Relevance 0.76 Pain Relevance 0
CPB is associated with activation of the complement system and the coagulation cascades which may contribute to the varying degrees of organ damage reported in the literature3 4.
CPB Binding (associated) of
5) Confidence 0.27 Published 2008 Journal Ulster Med J Section Body Doc Link PMC2516433 Disease Relevance 0.15 Pain Relevance 0.11
Cytokines play a key role in the inflammatory cascade associated with CPB [7,9].
CPB Binding (associated) of associated with inflammation and cytokine
6) Confidence 0.16 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 1.38 Pain Relevance 0.21
These results are in contrast to recent studies [28,29] reporting an association between low Hct during CPB and acute renal failure, although these studies were not able to show a cause-effect relationship for low Hct and acute renal failure.
CPB Binding (association) of associated with acute renal failure
7) Confidence 0.13 Published 2006 Journal Crit Care Section Body Doc Link PMC1550910 Disease Relevance 0.41 Pain Relevance 0.04
Moreover, an Hct as low as 20% during normothermic CPB was not associated with a higher incidence of acute renal failure (2/54 (3.7%) patients, 1 patient in each group), which confirms previous results [27].
CPB Binding (associated) of associated with acute renal failure
8) Confidence 0.13 Published 2006 Journal Crit Care Section Body Doc Link PMC1550910 Disease Relevance 0.39 Pain Relevance 0.05
As with any other patient who fails to separate from CPB, an aggressive search for the cause must be undertaken.
CPB Binding (separate) of
9) Confidence 0.05 Published 2006 Journal J Cardiothorac Surg Section Body Doc Link PMC1584228 Disease Relevance 0.47 Pain Relevance 0
The duration of CPB was directly associated with SOFA (p = 0.003, ?
CPB Binding (associated) of
10) Confidence 0.02 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.37 Pain Relevance 0
In general, however, there is a paucity of data that has focused on the association between specific intra-operative CPB parameters and risk of CSA-AKI [11].
CPB Binding (association) of associated with injury
11) Confidence 0.01 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2941753 Disease Relevance 1.08 Pain Relevance 0
A strong association between age and PASP as well as a more modest association with BMI in fenfluramine users has been previously reported and is consistent with our observations [25].
PASP Binding (association) of associated with obesity
12) Confidence 0.01 Published 2008 Journal BMC Med Section Body Doc Link PMC2585088 Disease Relevance 0.95 Pain Relevance 0
A strong association between age and PASP as well as a more modest association with BMI in fenfluramine users has been previously reported and is consistent with our observations [25].
PASP Binding (association) of associated with obesity
13) Confidence 0.01 Published 2008 Journal BMC Med Section Body Doc Link PMC2585088 Disease Relevance 0.95 Pain Relevance 0

General Comments

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