INT171773

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Context Info
Confidence 0.23
First Reported 2002
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 10.30
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
urine 1
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 5 100.00 Very High Very High Very High
Inflammation 140 97.04 Very High Very High Very High
cytokine 42 87.84 High High
ischemia 21 70.72 Quite High
Inflammatory response 26 69.44 Quite High
Potency 2 41.04 Quite Low
cINOD 6 40.00 Quite Low
adenocard 1 37.48 Quite Low
anesthesia 2 5.76 Low Low
Nicotine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 246 100.00 Very High Very High Very High
INFLAMMATION 174 100.00 Very High Very High Very High
Dermatological Disease 2 99.40 Very High Very High Very High
Psoriasis 2 98.88 Very High Very High Very High
Disease 116 97.64 Very High Very High Very High
Sepsis 134 96.76 Very High Very High Very High
Nicotine Addiction 369 95.72 Very High Very High Very High
Metastasis 12 94.72 High High
Necrosis 10 91.08 High High
Cancer 64 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interesting in this regard is a recent study by Jilma and colleagues in a human model of endotoxin-induced tissue-factor-triggered coagulation which found that the S128R mutation has no significant influence on the basal or inducible soluble E-selectin, but enhances thrombin generation substantially [31].
Neg (no) Regulation (influence) of E-selectin
1) Confidence 0.23 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 0.77 Pain Relevance 0
This scenario points to a possible link between changes in the E-selectin levels, endothelial dysfunction and manifestation of both diseases.
Spec (possible) Regulation (changes) of E-selectin associated with disease
2) Confidence 0.23 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.48 Pain Relevance 0
We investigated the predictive value of the mediators IL-6, IL-8, sELAM-1 and sICAM-1 and their time course in intensive care unit patients who developed septic shock with respect to outcome.


Spec (investigated) Regulation (value) of sELAM-1 associated with sepsis
3) Confidence 0.21 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1269435 Disease Relevance 0.73 Pain Relevance 0
We investigated the predictive value of the mediators IL-6, IL-8, sELAM-1 and sICAM-1 and their time course, as primary outcome measures, in intensive care unit (ICU) patients who developed septic shock with respect to outcome.
Spec (investigated) Regulation (value) of sELAM-1 associated with sepsis
4) Confidence 0.21 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.90 Pain Relevance 0.16
However, this observation was made in subjects with pustulosis palmaris et plantaris, a dermatological disease that seems to exert a strong influence on sE-selectin in serum, and it is not clear how the incidence of this confounding condition was distributed between the smoking and non-smoking groups.
Regulation (influence) of sE-selectin associated with psoriasis, nicotine addiction and dermatological disease
5) Confidence 0.18 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.60 Pain Relevance 0
However, this observation was made in subjects with pustulosis palmaris et plantaris, a dermatological disease that seems to exert a strong influence on sE-selectin in serum, and it is not clear how the incidence of this confounding condition was distributed between the smoking and non-smoking groups.
Regulation (influence) of sE-selectin associated with psoriasis, nicotine addiction and dermatological disease
6) Confidence 0.18 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.60 Pain Relevance 0
Cell adhesion molecules such as E-selectin, ICAM-1, and VCAM-1, are regulated by NF-?
Regulation (regulated) of E-selectin associated with adhesions
7) Confidence 0.16 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234426 Disease Relevance 0.98 Pain Relevance 0
They as O'Brien found that E-Selectin, ICAM and VCAM were up regulated.
Regulation (regulated) of E-Selectin
8) Confidence 0.14 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.03 Pain Relevance 0.12
Although fewer studies have been performed, the results have been mixed with respect to the effect of ALA on inflammatory markers such as C-reactive protein, vascular cellular adhesion molecule-1, E-selectin, and interleukin-6.
Regulation (effect) of E-selectin associated with inflammatory marker and adhesions
9) Confidence 0.04 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.86 Pain Relevance 0.09
, RANTES, histamine: Beckman-Coulter, Krefeld, Germany; IL-4, IL-10, IL-13, soluble intracellular adhesion molecule-1 (sICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM): Bender MedSystems, Vienna, Austria; IL-5, IL-6 high sensitivity, IL-10 high sensitivity, IL-12 p40/p70, soluble leukocytic (sL)-selectin, sE-selectin: R&D Systems GmbH, Wiesbaden, Germany; IL-2, IL-2-receptor, serum and urine neopterin: DPC Biermann GmbH, Bad Nauheim, Germany; IL-4 high sensitivity, IL-11: Natutec, Frankfurt, Germany; IL-12 p70, IL-13: Biozol Diagnostica Ver-trieb GmbH, Eching, Germany; C5a: Behringwerke AG, Marburg, Germany].
Regulation (sensitivity) of sE-selectin in urine associated with adhesions
10) Confidence 0.02 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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