INT171816

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Context Info
Confidence 0.20
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.67
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Stx1a) protein binding, bridging (Stx1a) protein complex (Stx1a)
Anatomy Link Frequency
dorsal 1
bands 1
optic 1
neuropil 1
Stx1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 148 99.92 Very High Very High Very High
Dorsal horn 40 98.40 Very High Very High Very High
Glutamate 136 97.36 Very High Very High Very High
imagery 3 95.28 Very High Very High Very High
gABA 24 91.84 High High
Neuropathic pain 14 82.56 Quite High
adenocard 2 78.16 Quite High
antidepressant 52 75.20 Quite High
Lasting pain 2 71.44 Quite High
Spinal nerve ligature 22 68.72 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 25 95.64 Very High Very High Very High
Death 5 94.84 High High
Stress 219 88.60 High High
Neuropathic Pain 20 82.56 Quite High
Targeted Disruption 8 80.88 Quite High
Pain 24 70.56 Quite High
Optic Disorders 28 50.00 Quite Low
Urological Neuroanatomy 12 50.00 Quite Low
Apoptosis 5 11.76 Low Low
Nociception 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All bands used were within linear range of standard curves, and normalized for syntaxin-1 monomer levels in the same membrane.
Gene_expression (levels) of syntaxin-1 in bands
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0 Pain Relevance 0.11
First, we measured the general expression of the SNAREs (synaptobrevin, syntaxin-1 and SNAP-25, the three proteins forming the core exocytotic SNARE complex) as well as their levels in synaptosomes; no changes were found in all rat groups (not shown).
Gene_expression (expression) of syntaxin-1
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.62 Pain Relevance 0.31
Syntaxin 1A has previously been shown to be preferentially expressed in the dorsal spinal cord neuropil.
Gene_expression (expressed) of Syntaxin 1A in dorsal associated with spinal cord
3) Confidence 0.09 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC126259 Disease Relevance 0.37 Pain Relevance 0.38
The brain slices of the rats, sacrificed 2 months after rotenone administration, were stained with neuron specific antibody NeuN and the number of neuron cells remaining in the optic layer of the SC was counted (Figure 6A).
Gene_expression (stained) of neuron specific antibody NeuN in optic
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900204 Disease Relevance 0.47 Pain Relevance 0
Galpha(olf) and Syntaxin 1A appear to be localized in the neuropil of the dorsal horn (Fig. 3A and 3B) whereas, PKC?
Gene_expression (appear) of Syntaxin 1A in neuropil associated with dorsal horn
5) Confidence 0.07 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC126259 Disease Relevance 0.22 Pain Relevance 0.84

General Comments

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