INT171848

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Context Info
Confidence 0.27
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.24
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsa) mitochondrion (Ctsa) nucleus (Ctsa)
lysosome (Ctsa)
Anatomy Link Frequency
synovial fluid 1
Ctsa (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 71 99.16 Very High Very High Very High
Inflammation 171 99.12 Very High Very High Very High
cytokine 30 86.24 High High
imagery 121 75.00 Quite High
metalloproteinase 71 70.56 Quite High
Inflammatory response 13 62.32 Quite High
Arthritis 11 56.88 Quite High
Hippocampus 5 35.20 Quite Low
Osteoarthritis 19 26.52 Quite Low
Pyramidal cell 6 19.84 Low Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 4 99.48 Very High Very High Very High
Polyps 160 99.44 Very High Very High Very High
Rheumatoid Arthritis 112 99.16 Very High Very High Very High
INFLAMMATION 187 99.12 Very High Very High Very High
Cancer 172 94.76 High High
Targeted Disruption 22 93.92 High High
Familial Adenomatous Polyposis 176 92.00 High High
Intestinal Polyps 4 88.68 High High
Cleidocranial Dysplasia 60 85.08 High High
Adenoma 36 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, attenuation of polyposis in these mice suggests a specific requirement for cathepsin B in the progressive growth of polyps.
Positive_regulation (requirement) of cathepsin associated with polyps
1) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.09 Pain Relevance 0.10
Using biotinylated suicide inhibitors we quantified increased activities of the Cathepsin B & Z in the polyps.
Positive_regulation (increased) of Cathepsin associated with suicidal behaviour and polyps
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2488397 Disease Relevance 0.84 Pain Relevance 0.14
The increased signal of the ProSense 680 in microadenoma is attributed to increased local cathepsin activity.
Positive_regulation (increased) of cathepsin
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.49 Pain Relevance 0
0.9999, total number of values 60), suggesting that the increase in signal intensity was due to an increase in the numbers of cathepsin active cells.
Positive_regulation (increase) of cathepsin
4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.41 Pain Relevance 0
In addition, rapamycin increased the levels of LC3 and Cathepsin D immunoreactivity (Figure 8O, P).
Positive_regulation (increased) of Cathepsin
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.32 Pain Relevance 0
In addition, inflammation associated with PAR2 stimulation led to an up-regulation of serpine 1, WT1, cyclin D1, IGF1R, and cathepsin K.


Positive_regulation (up-regulation) of cathepsin associated with inflammation
6) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.30 Pain Relevance 0.15
Accumulation of active cathepsin B in the synovial fluid of RA patients is probably related to destruction of subchondral bone [44].
Positive_regulation (Accumulation) of cathepsin in synovial fluid associated with rheumatoid arthritis
7) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.84 Pain Relevance 0.54
Another promising approach that is aimed at modulating the terminal phase of MMP and cathepsin upregulation by cleaving the messenger RNA for these enzymes.
Positive_regulation (upregulation) of cathepsin
8) Confidence 0.01 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 0.95 Pain Relevance 0.20

General Comments

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