INT171851

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 10.70
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sumo1) transcription factor binding (Sumo1) response to stress (Sumo1)
cytoplasm (Sumo1)
Anatomy Link Frequency
synovium 3
Sumo1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 184 99.84 Very High Very High Very High
imagery 3 91.88 High High
cva 63 79.72 Quite High
Inflammation 126 75.00 Quite High
cytokine 106 59.76 Quite High
ischemia 123 53.52 Quite High
aspirin 24 46.84 Quite Low
Arthritis 29 40.64 Quite Low
metalloproteinase 53 5.00 Very Low Very Low Very Low
isoflurane 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 72 100.00 Very High Very High Very High
Rheumatoid Arthritis 348 99.84 Very High Very High Very High
Infarction 72 99.34 Very High Very High Very High
Death 13 99.32 Very High Very High Very High
Embolism 63 99.12 Very High Very High Very High
Myeloproliferative Disorder 154 98.96 Very High Very High Very High
Cancer 90 98.00 Very High Very High Very High
Hematological Disease 42 97.86 Very High Very High Very High
Necrosis 12 97.52 Very High Very High Very High
Brain Hemorrhage 3 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CBF was measured before embolic infarction (100% baseline), after embolic infarction, and at 0, 1, 3, and 24 h after injection of t-PA or SMTP-7 in accordance with the manufacturer's instructions.
Gene_expression (injection) of SMTP-7 associated with embolism and infarction
1) Confidence 0.30 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2926440 Disease Relevance 0.40 Pain Relevance 0.05
In order to evaluate the mechanism of SMTP-7, plasmin activities and the expressions of interleukin (IL)-1?
Gene_expression (expressions) of SMTP-7
2) Confidence 0.27 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Abstract Doc Link PMC2926440 Disease Relevance 0.99 Pain Relevance 0.20
Fig. 1Structure of SMTP-7 (Orniplabin; CAS registry No. 273379-50-3)
Gene_expression (1Structure) of SMTP-7
3) Confidence 0.26 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2926440 Disease Relevance 0.71 Pain Relevance 0.03
Sentrin interferes with Fas-induced as well as TNF-induced apoptosis, and was shown to be highly expressed in RASFs at sites of synovial invasion [67].
Gene_expression (expressed) of Sentrin associated with apoptosis
4) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.08 Pain Relevance 0.07
However, further experiments will be required to completely exclude other possible explanations for the long-term engraftment of miR-29a–expressing myeloid progenitors, including that long-term engrafted miR-29a–overexpressing CMP and GMP represent the progeny of rare engrafted HSC exhibiting a strongly biased myeloid differentiation potential, and that the transplanted and/or engrafted immunophenotypic myeloid progenitors may represent abnormal HSC with altered surface marker expression.
Gene_expression (overexpressing) of GMP
5) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.68 Pain Relevance 0
Overexpression of miR-29a enhances proliferation of MPP and 293T cells but does not significantly alter MPP self-renewal, yet overexpression of miR-29a in CMP or GMP is sufficient to induce self-renewal but not proliferation, suggesting that miR-29a exerts stage-specific and cell context–specific effects.
Gene_expression (overexpression) of GMP
6) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.39 Pain Relevance 0
Interestingly, sentrin is found mainly in rheumatoid arthritis synovial lining cells, whereas normal synovium cells express only very little sentrin messenger RNA [37].
Gene_expression (found) of sentrin in synovium associated with rheumatoid arthritis
7) Confidence 0.04 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 1.43 Pain Relevance 0.13
As for possible mechanisms that may extend the life-span of lining layer RA-SFs, we have demonstrated most recently [37] that the novel antiapoptotic molecule sentrin is strongly expressed in rheumatoid arthritis synovium.
Gene_expression (expressed) of sentrin in synovium associated with rheumatoid arthritis
8) Confidence 0.04 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 1.24 Pain Relevance 0.16
Therefore, it is suggested that inhibiting the expression of sentrin in RA-SFs may reduce their invasiveness through interfering with altered apoptosis and normalizing the life-span of these cell.
Gene_expression (expression) of sentrin associated with rheumatoid arthritis and apoptosis
9) Confidence 0.04 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 1.41 Pain Relevance 0.12
Using unsupervised clustering and SAM analysis with a stringent cutoff (FDR < 1%), we determined that miR-29a consistently showed higher expression levels in HSC and MPP compared with more committed myeloid progenitors, with HSC/MPP showing an approximately three- to fourfold higher expression than the more mature progenitor populations (MEP and GMP; P < 0.005; Fig. 1, a and b).
Gene_expression (expression) of GMP
10) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.11 Pain Relevance 0
We sorted MPP, CMP, and GMP from control (WT or empty retrovirus–transduced chimeric mice) or miR-29a–overexpressing primary chimeric mice before MPD development (?
Gene_expression (overexpressing) of GMP associated with myeloproliferative disorder
11) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.28 Pain Relevance 0
Neither miR-29a–expressing GMP nor CMP exhibited significant differences in proliferative capacity compared with their WT counterparts.
Gene_expression (expressing) of GMP
12) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.15 Pain Relevance 0
To assess the stage of hematopoiesis at which miR-29a exerts its promyeloid differentiation and proliferative effects, we sorted MPP, CMP, and GMP from miR-29a–expressing chimeric mice and assessed the ability of single sorted progenitors to proliferate and differentiate in vitro using liquid cultures. miR-29a MPP (Lin?
Gene_expression (expressing) of GMP associated with hematological disease
13) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.23 Pain Relevance 0
Mice transplanted with miR-29a–expressing CMP or GMP possessed donor-derived CMP and GMP, respectively, as well as their differentiated GFP+ progeny (Mac1+Gr-1+ cells), even 2 mo after the transplantation (Fig. 3 e).
Gene_expression (expressing) of GMP
14) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.16 Pain Relevance 0
Interestingly, sentrin is found mainly in rheumatoid arthritis synovial lining cells, whereas normal synovium cells express only very little sentrin messenger RNA [37].
Gene_expression (express) of sentrin in synovium associated with rheumatoid arthritis
15) Confidence 0.03 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 1.45 Pain Relevance 0.13

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