INT17187

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Context Info
Confidence 0.16
First Reported 1991
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.61

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cytoplasm (Adra2a, Fabp6) cytosol (Fabp6) signal transduction (Adra2a)
plasma membrane (Adra2a) signal transducer activity (Adra2a)
Anatomy Link Frequency
anterior 2
Adra2a (Rattus norvegicus)
Fabp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 14 94.96 High High
Disease Link Frequency Relevance Heat
Hypertension 10 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that dietary NaCl supplementation increases blood pressure and sympathetic nervous system activity in association with decreased norepinephrine release and increased alpha 2-adrenergic receptor number in the anterior hypothalamic area of salt-sensitive spontaneously hypertensive rats (SHR-S) but not in salt-resistant spontaneously hypertensive rats (SHR-R) or Wistar-Kyoto (WKY) rats.
alpha 2-adrenergic Binding (association) of SHR-R in anterior associated with hypertension
1) Confidence 0.16 Published 1991 Journal Hypertension Section Abstract Doc Link 1885231 Disease Relevance 0.35 Pain Relevance 0.31
We have previously shown that dietary NaCl supplementation increases blood pressure and sympathetic nervous system activity in association with decreased norepinephrine release and increased alpha 2-adrenergic receptor number in the anterior hypothalamic area of salt-sensitive spontaneously hypertensive rats (SHR-S) but not in salt-resistant spontaneously hypertensive rats (SHR-R) or Wistar-Kyoto (WKY) rats.
alpha 2-adrenergic Binding (association) of SHR-S in anterior associated with hypertension
2) Confidence 0.16 Published 1991 Journal Hypertension Section Abstract Doc Link 1885231 Disease Relevance 0.34 Pain Relevance 0.29

General Comments

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