INT171885

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.27
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lifr) plasma membrane (Lifr)
Anatomy Link Frequency
liver 1
Lifr (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 42 87.08 High High
cytokine 32 86.88 High High
methotrexate 1 49.00 Quite Low
Arthritis 52 18.68 Low Low
Inflammation 18 10.68 Low Low
addiction 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 126 99.08 Very High Very High Very High
Leukemia 4 96.56 Very High Very High Very High
Rheumatoid Arthritis 42 87.08 High High
Lifespan 94 85.20 High High
Body Weight 2 74.64 Quite High
Calcification 2 70.80 Quite High
Obesity 2 64.16 Quite High
Stress 12 53.80 Quite High
Experimental Arthritis 8 18.68 Low Low
Liver Disease 2 15.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While there are several molecules that Lifr may interact with [41-43], Lifr expression is a primary determinant of cellular responsiveness to leukemia inhibitory factor (Lif) [44].
Lifr Binding (interact) of associated with leukemia
1) Confidence 0.34 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.90 Pain Relevance 0.04
Determining whether Lifr downregulation in liver contributes to longevity extension represents a difficult task, since Lifr is highly pleiotropic and has been associated with a wide range of biological effects.
Lifr Binding (associated) of in liver associated with aging
2) Confidence 0.23 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 1.01 Pain Relevance 0.04
In addition, the TNF soluble receptor used in some of the anti-TNF trials not only binds to TNF but also scavenges lymphotoxin.
soluble receptor Binding (binds) of
3) Confidence 0.01 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.35 Pain Relevance 0.22

General Comments

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