INT171889

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Context Info
Confidence 0.08
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
macrophage 2
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 164 99.78 Very High Very High Very High
cytokine 113 89.32 High High
rheumatoid arthritis 55 89.12 High High
chemokine 10 78.68 Quite High
Inflammatory response 5 72.76 Quite High
Inflammation 53 64.96 Quite High
tolerance 2 18.48 Low Low
Inflammatory mediators 2 11.20 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 183 99.78 Very High Very High Very High
Infection 8 99.00 Very High Very High Very High
Necrosis 88 97.36 Very High Very High Very High
Rheumatoid Arthritis 56 89.12 High High
Encephalitis 2 85.92 High High
Apoptosis 20 80.72 Quite High
INFLAMMATION 45 72.40 Quite High
Immunization 8 68.08 Quite High
Injury 26 49.28 Quite Low
Experimental Arthritis 8 47.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also measured basal levels of IL-1ra – the natural inhibitor of IL-1?
Negative_regulation (inhibitor) of Gene_expression (levels) of IL-1ra
1) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.66 Pain Relevance 0.25
The occurrence of spontaneous arthritis, when the IL-1ra deficiency was backcrossed to a Balb/c genetic background, illustrates the continued arthritogenic pressure of environmental stimuli, resulting in the generation of IL-1, which is normally controlled by endogenous IL-1ra.
Negative_regulation (backcrossed) of Gene_expression (deficiency) of IL-1ra associated with arthritis
2) Confidence 0.04 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 1.05 Pain Relevance 0.47
In addition, in these mice, there was an increase of levels in IL-10 and IL-1Ra and IL-6 following hAFSC injection (similar to that noted in the mice injected with hAFSC following ATN), there was no increase in SDF-1 and also they expressed lower levels of NK attractors as well as macrophage attractors.
Negative_regulation (increase) of Gene_expression (levels) of IL-1Ra in macrophage associated with necrosis
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.60 Pain Relevance 0.18

General Comments

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