INT171901

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Context Info
Confidence 0.18
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
cartilage 1
TNF (Homo sapiens)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 50 97.96 Very High Very High Very High
cytokine 34 97.60 Very High Very High Very High
Arthritis 52 96.12 Very High Very High Very High
Potency 2 74.96 Quite High
rheumatoid arthritis 42 64.40 Quite High
chemokine 1 61.80 Quite High
addiction 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 23 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
INFLAMMATION 42 97.96 Very High Very High Very High
Arthritis 56 96.12 Very High Very High Very High
Targeted Disruption 7 90.96 High High
Rheumatoid Arthritis 42 64.40 Quite High
Pressure And Volume Under Development 2 29.72 Quite Low
Disease 9 25.00 Low Low
Colon Cancer 15 5.00 Very Low Very Low Very Low
Adenoma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, IL-1 is much more potent than TNF in inducing cartilage destruction in vivo.
TNF Binding (potent) of IL-1 in cartilage
1) Confidence 0.18 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.70 Pain Relevance 0.54
We assessed its anticancer activity by screening interleukin-1, 6, and 12 (IL-1, 6, 12), secretory levels of tumor necrosis factor-alpha (TNF-?)
TNF Binding (interleukin-1) of IL-1 associated with necrosis and cancer
2) Confidence 0.04 Published 2010 Journal International Journal of Inflammation Section Abstract Doc Link PMC3004002 Disease Relevance 0.37 Pain Relevance 0.16

General Comments

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