INT171905

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.08
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 100.00 Very High Very High Very High
Arthritis 52 97.08 Very High Very High Very High
cytokine 91 94.28 High High
Inflammation 129 86.16 High High
rheumatoid arthritis 43 81.44 Quite High
Inflammatory mediators 24 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 56 97.08 Very High Very High Very High
Experimental Arthritis 8 95.08 Very High Very High Very High
INFLAMMATION 155 86.16 High High
Rheumatoid Arthritis 43 81.44 Quite High
Adhesions 14 74.24 Quite High
Otitis Media 134 62.68 Quite High
Hypercalcemia 4 56.80 Quite High
Otitis Media With Effusion 92 56.32 Quite High
Hemophilus Infection 1 48.24 Quite Low
Infection 15 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further insight into the relative roles of TNF and IL-1, as well as the TNF dependence of IL-1 production under various arthritogenic conditions, has emerged from the efficacy of TNF and IL-1 blocking in a range of well-defined experimental arthritis models (Table 1).
TNF Positive_regulation (dependence) of Gene_expression (production) of IL-1 associated with addiction, experimental arthritis and arthritis
1) Confidence 0.23 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.55 Pain Relevance 0.45
TNF also stimulates synthesis of IL-1 (14).
TNF Positive_regulation (stimulates) of Gene_expression (synthesis) of IL-1
2) Confidence 0.02 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.53 Pain Relevance 0.09

General Comments

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