INT171907

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Context Info
Confidence 0.06
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8, MAPK14) nucleoplasm (MAPK8, MAPK14) nucleus (MAPK8, MAPK14)
response to stress (MAPK8, MAPK14) cytoplasm (MAPK8, MAPK14) signal transduction (MAPK14)
MAPK8 (Homo sapiens)
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 32 98.78 Very High Very High Very High
cytokine 12 95.76 Very High Very High Very High
Inflammation 10 88.00 High High
metalloproteinase 3 65.16 Quite High
Arthritis 7 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 32 98.78 Very High Very High Very High
Osteoarthritis 6 96.40 Very High Very High Very High
Stress 65 94.72 High High
INFLAMMATION 9 88.00 High High
Synovitis 5 69.92 Quite High
Death 6 68.12 Quite High
Apoptosis 9 67.68 Quite High
Shock 9 20.08 Low Low
Heat Stress Disorders 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the synovial membrane of RA patients, all three known MAPK/SAPK signalling pathways are activated, including the extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK) and p38 pathways [58,59].
JNK Positive_regulation (activated) of Gene_expression (pathways) of p38 associated with rheumatoid arthritis
1) Confidence 0.06 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 0.77 Pain Relevance 0.26

General Comments

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