INT171910

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Context Info
Confidence 0.10
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.55
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1, MAPK9) mitochondrion (MAPK1, MAPK9) response to stress (MAPK1, MAPK9)
cytoplasm (MAPK1, MAPK9) cytosol (MAPK1, MAPK9) nucleus (MAPK1, MAPK9)
MAPK1 (Homo sapiens)
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 64 99.36 Very High Very High Very High
cytokine 24 96.92 Very High Very High Very High
Inflammation 20 83.76 Quite High
metalloproteinase 6 66.32 Quite High
Arthritis 14 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 64 99.36 Very High Very High Very High
Stress 130 95.88 Very High Very High Very High
Osteoarthritis 12 92.16 High High
INFLAMMATION 18 83.76 Quite High
Synovitis 10 71.08 Quite High
Death 12 69.28 Quite High
Apoptosis 18 68.84 Quite High
Shock 18 21.24 Low Low
Heat Stress Disorders 16 5.00 Very Low Very Low Very Low
Arthritis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the synovial membrane of RA patients, all three known MAPK/SAPK signalling pathways are activated, including the extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK) and p38 pathways [58,59].
ERK Positive_regulation (activated) of SAPK associated with rheumatoid arthritis
1) Confidence 0.10 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 0.77 Pain Relevance 0.26
In the synovial membrane of RA patients, all three known MAPK/SAPK signalling pathways are activated, including the extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK) and p38 pathways [58,59].
extracellular signal-regulated protein kinase Positive_regulation (activated) of SAPK associated with rheumatoid arthritis
2) Confidence 0.10 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 0.77 Pain Relevance 0.26

General Comments

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