INT171922

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.31
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
Anatomy Link Frequency
fibroblasts 2
upper 2
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 106 99.54 Very High Very High Very High
rheumatoid arthritis 32 87.20 High High
Arthritis 7 63.60 Quite High
Inflammation 12 42.16 Quite Low
metalloproteinase 9 27.60 Quite Low
addiction 6 18.12 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 9 98.86 Very High Very High Very High
Stress 66 97.94 Very High Very High Very High
Rheumatoid Arthritis 32 87.20 High High
Contracture 8 72.48 Quite High
Arthritis 6 63.60 Quite High
Equinus Deformity 1 63.08 Quite High
Heat Stress Disorders 8 55.44 Quite High
Hyperplasia 1 55.44 Quite High
Pressure And Volume Under Development 12 49.00 Quite Low
Disease 20 45.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig. 7Foot splints can also be held to the fixator using Velcro straps
Positive_regulation (held) of Fig Binding (splints) of
1) Confidence 0.44 Published 2006 Journal Strategies Trauma Limb Reconstr Section Body Doc Link PMC2780592 Disease Relevance 0.20 Pain Relevance 0
As for the soluble species, total free VEGF in all compartments decreased with increasing VEGF-binding affinity of either VEGFR1 or VEGFR2 – presumably through enhanced internalization of complexed VEGF (Fig. 6B).
Positive_regulation (increasing) of Fig Binding (internalization) of
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
As for the soluble species, total free VEGF in all compartments decreased with increasing VEGF-binding affinity of either VEGFR1 or VEGFR2 – presumably through enhanced internalization of complexed VEGF (Fig. 6B).
Positive_regulation (enhanced) of Fig Binding (internalization) of
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Furthermore, agonist stimulation caused an increased association between the hIP and Rab5aS34N (Fig. 5; upper panel).
Positive_regulation (increased) of Fig Binding (association) of in upper associated with agonist
4) Confidence 0.11 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.26
Interestingly, recent data from our laboratory have shown that shear stress induces a complete response of the heat shock factor (HSF)-1/HSP70 pathway in synovial fibroblasts by inducing DNA binding of HSF-1 (Fig. 1) and the subsequent overexpression of HSP70 [11].
Positive_regulation (inducing) of Fig Binding (binding) of in fibroblasts associated with stress and shock
5) Confidence 0.09 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.11 Pain Relevance 0.08

General Comments

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