INT171924

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2011
Negated 3
Speculated 3
Reported most in Body
Documents 60
Total Number 83
Disease Relevance 54.38
Pain Relevance 21.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14)
nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)
Anatomy Link Frequency
chondrocytes 10
cartilage 1
finger 1
brain 1
central nervous system 1
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 3249 100.00 Very High Very High Very High
Inflammation 1154 100.00 Very High Very High Very High
cytokine 1120 100.00 Very High Very High Very High
Central nervous system 296 99.98 Very High Very High Very High
Nicotine 384 99.20 Very High Very High Very High
COX2 1 98.80 Very High Very High Very High
IPN 4 98.50 Very High Very High Very High
agonist 119 98.24 Very High Very High Very High
rheumatoid arthritis 891 97.36 Very High Very High Very High
Arthritis 345 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1398 100.00 Very High Very High Very High
INFLAMMATION 1205 100.00 Very High Very High Very High
Frailty 331 100.00 Very High Very High Very High
Stress 330 100.00 Very High Very High Very High
Osteoarthritis 3005 99.72 Very High Very High Very High
Disease Progression 122 99.40 Very High Very High Very High
Cold Sores 367 99.20 Very High Very High Very High
Cancer 720 98.64 Very High Very High Very High
Inflammatory Pain 4 98.50 Very High Very High Very High
Apoptosis 580 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To analyze the gene expression of the p38-MAPK isoforms ?
Spec (analyze) Gene_expression (expression) of p38
1) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0 Pain Relevance 0.09
Expression of p38-MAPK isoforms in human OA chondrocytes
Gene_expression (Expression) of p38 in chondrocytes associated with osteoarthritis
2) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.98 Pain Relevance 0.42
-MAPK but not p38?
Gene_expression (but) of p38
3) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.01 Pain Relevance 0.44
-MAPK and p38?
Gene_expression (MAPK) of p38
4) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.68 Pain Relevance 0.37
Next, we examined which p38-MAPK isoform was activated by IL-1?
Spec (examined) Gene_expression (examined) of p38
5) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.67 Pain Relevance 0.33
antibody (#MAB1347) was from R&D Systems (Minneapolis, MN, USA); anti-phospho-p38MAPK antibody (#9215S), anti-p38?
Gene_expression (antibody) of p38
6) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.19 Pain Relevance 0.10
We next examined the gene expression pattern of p38-MAPK isoforms in primary human OA chondrocytes by PCR using the gene specific primers (see method section).
Spec (examined) Gene_expression (expression) of p38 in chondrocytes associated with osteoarthritis
7) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.92 Pain Relevance 0.39
[36], however, activation of endogenously expressed p38-MAPK family members by IL-1?
Gene_expression (expressed) of p38
8) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.63 Pain Relevance 0.31
Anti-p38?
Gene_expression (Anti) of p38
9) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.20 Pain Relevance 0.10
In the decomposition of the interaction map, FOS appears in Module 2 only and MAPK14 catalyzes the activation of FOS.
Gene_expression (catalyzes) of MAPK14
10) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.48 Pain Relevance 0.17
-MAPK isoform was undetectable in human OA chondrocytes, HeLa cells and the C28-I2 chondrocytes indicating that these cell types do not express p38?
Neg (not) Gene_expression (express) of p38 in chondrocytes associated with osteoarthritis
11) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.72 Pain Relevance 0.40
Our results show that expression of p38?
Gene_expression (expression) of p38
12) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.89 Pain Relevance 0.38
Gene expression of p38-MAPK isoforms was measured by RT-PCR.
Gene_expression (expression) of p38
13) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991031 Disease Relevance 0.63 Pain Relevance 0.32
Interestingly, the expression of p38?
Gene_expression (expression) of p38
14) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.62 Pain Relevance 0.31
Ours results show that in human OA chondrocytes expression of p38?
Gene_expression (expression) of p38 in chondrocytes associated with osteoarthritis
15) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.54 Pain Relevance 0.27
Human OA chondrocytes expressed p38-MAPK isoforms p38?
Gene_expression (expressed) of p38 in chondrocytes associated with osteoarthritis
16) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991031 Disease Relevance 0.75 Pain Relevance 0.38
Human OA chondrocytes expressed p38-MAPK isoforms p38?
Gene_expression (expressed) of p38 in chondrocytes associated with osteoarthritis
17) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991031 Disease Relevance 0.75 Pain Relevance 0.37
proteins was readily detected but the expression of p38?
Gene_expression (expression) of p38
18) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.53 Pain Relevance 0.27
We thus conclude that human OA chondrocytes do not express the p38?
Neg (not) Gene_expression (express) of p38 in chondrocytes associated with osteoarthritis
19) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.68 Pain Relevance 0.34
Although the relative expression of p38-MAPK isoforms in osteoarthritis has not been fully explored, but the best-studied is p38?
Gene_expression (expression) of p38 associated with osteoarthritis
20) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.13 Pain Relevance 0.60

General Comments

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