INT171939

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Context Info
Confidence 0.05
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 6.80
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-DOA, TNF) endosome (HLA-DOA) signal transduction (TNF)
extracellular space (TNF) extracellular region (TNF) intracellular (TNF)
HLA-DOA (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 79.00 Quite High
antagonist 16 69.76 Quite High
rheumatoid arthritis 32 47.04 Quite Low
cytokine 8 36.96 Quite Low
chemokine 20 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 12 100.00 Very High Very High Very High
Cancer 12 100.00 Very High Very High Very High
Polymyalgia Rheumatica 152 99.40 Very High Very High Very High
Genetic Predisposition To Disease 4 98.08 Very High Very High Very High
Giant Cell Arteritis 156 94.08 High High
Adhesions 20 80.96 Quite High
INFLAMMATION 20 79.00 Quite High
Disease 32 62.96 Quite High
Hypersensitivity 4 56.20 Quite High
Rheumatoid Arthritis 32 47.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, TNF and HLA associations appear to be able to influence susceptibility to these conditions independently of each other.


HLA Binding (associations) of TNF
1) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.73 Pain Relevance 0.07
Besides associations with HLA, tumor necrosis factor appears to influence susceptibility to both conditions.
HLA Binding (associations) of tumor necrosis factor associated with necrosis and cancer
2) Confidence 0.05 Published 2001 Journal Arthritis Res Section Abstract Doc Link PMC128892 Disease Relevance 1.47 Pain Relevance 0.03
Thus, TNF and HLA associations appear to be able to influence susceptibility to these conditions independently of each other.


HLA Binding (associations) of TNF
3) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.73 Pain Relevance 0.07
In contrast, in patients with isolated PMR, there is a positive association with TNF-b3, which is also independent of the HLA class II association with isolated PMR, and a negative association with TNF-d4 [7].
HLA Binding (association) of TNF-b3 associated with polymyalgia rheumatica
4) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.87 Pain Relevance 0.08

General Comments

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