INT17195

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.37
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gstp1) plasma membrane (Gstp1) nucleus (Gstp1)
intracellular (Gstp1) protein complex (Gstp1) cytoplasm (Gstp1)
Anatomy Link Frequency
liver 5
thyroid 4
hepatocytes 2
Gstp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 32 98.98 Very High Very High Very High
qutenza 10 96.24 Very High Very High Very High
Central nervous system 6 86.32 High High
Dopamine 50 84.12 Quite High
anesthesia 11 84.00 Quite High
agonist 48 77.16 Quite High
Glutamate 9 72.40 Quite High
gABA 4 25.28 Quite Low
Neurotransmitter 7 19.04 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 4 100.00 Very High Very High Very High
Hyperplasia 29 99.74 Very High Very High Very High
Cirrhosis 18 99.30 Very High Very High Very High
Apoptosis 21 98.64 Very High Very High Very High
Parkinson's Disease 1 96.52 Very High Very High Very High
Stress 24 96.36 Very High Very High Very High
Targeted Disruption 21 96.36 Very High Very High Very High
Disease 8 95.96 Very High Very High Very High
Death 9 94.92 High High
Hepatomegaly 2 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of age on the induction of glutathione S-transferase placental form (GST-P)-positive hepatic foci in rats were examined using a medium-term liver bioassay system (for carcinogens).
Positive_regulation (induction) of GST-P in liver
1) Confidence 0.67 Published 1991 Journal Jpn. J. Cancer Res. Section Abstract Doc Link 1902451 Disease Relevance 0 Pain Relevance 0.22
After 13-wk treatment, glutathione S-transferase placental form (GST-P)-positive liver cell foci were significantly increased in NPYR-treated and IQ-treated rats.
Positive_regulation (increased) of glutathione S-transferase placental in liver
2) Confidence 0.66 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15486947 Disease Relevance 0.36 Pain Relevance 0.25
Pretreatment with AAP (600mg) 48 or 72h before 1 or 2mg AFB(1) produced increases in both GST-P positive hepatocytes and minifoci.
Positive_regulation (increases) of GST-P in hepatocytes associated with paracetamol
3) Confidence 0.66 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11463488 Disease Relevance 0.13 Pain Relevance 0.70
In contrast, continuous feeding of CD diet or 0.5% phenobarbital treatment after generation of cirrhosis with CD diet clearly enhanced the induction of both GST-P and GGT-positive liver lesions.
Positive_regulation (induction) of GST-P in liver associated with cirrhosis
4) Confidence 0.65 Published 1990 Journal Carcinogenesis Section Abstract Doc Link 2347065 Disease Relevance 0.26 Pain Relevance 0.07
The biologic significance of increased GST-pi (Gstp2) transcripts in the rat thyroid is uncertain but may be predictive of increased oxidative stress.
Positive_regulation (increased) of Gstp2 in thyroid associated with stress
5) Confidence 0.61 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.16 Pain Relevance 0
The biologic significance of increased GST-pi (Gstp2) transcripts in the rat thyroid is uncertain but may be predictive of increased oxidative stress.
Positive_regulation (increased) of GST-pi in thyroid associated with stress
6) Confidence 0.61 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.16 Pain Relevance 0
IMPLICATIONS: Sevoflurane delivered in a 3% concentration with a fresh gas flow of 1 L/min for 4 h generated an average maximal Compound A concentration of 39 ppm but did not result in any significant increase in sensitive markers of renal function or injury, including urinary protein, albumin, glucose, and alpha- and pi-glutathione-S-transferase.
Positive_regulation (increase) of pi-glutathione-S-transferase associated with injury
7) Confidence 0.60 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9495434 Disease Relevance 0.33 Pain Relevance 0.36
In our study, GST-pi mRNA was significantly increased (150% of control) in the thyroid of rats exposed to the lowest dose of NaI tested (0.1 mg/kg/day).
Positive_regulation (increased) of GST-pi in thyroid
8) Confidence 0.53 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.14 Pain Relevance 0
After 13-wk treatment, glutathione S-transferase placental form (GST-P)-positive liver cell foci were significantly increased in NPYR-treated and IQ-treated rats.
Positive_regulation (increased) of GST-P in liver
9) Confidence 0.44 Published 2005 Journal Mol. Carcinog. Section Abstract Doc Link 15486947 Disease Relevance 0.36 Pain Relevance 0.24
Effects of acetaminophen (AAP) pretreatment on hepatic aflatoxin B1 (AFB(1))-DNA binding, cellular proliferation, and AFB(1)-induced glutathione S-transferase placental form (GST-P) positive hepatocytes and foci have been examined in young male rats and hamsters.
Positive_regulation (induced) of GST-P in hepatocytes associated with paracetamol and hyperplasia
10) Confidence 0.44 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11463488 Disease Relevance 0.17 Pain Relevance 0.50
Dose-dependent increases in the antioxidant enzyme transcripts Gpx2 and Gstp2 observed in the rat thyroid are consistent with a compensatory response to the generation of lipid peroxides as reported by Vitale et al. (2000) using iodide exposures in vitro.
Positive_regulation (increases) of Gstp2 in thyroid
11) Confidence 0.41 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.40 Pain Relevance 0
The induction of GST-P+ hepatic foci in rats treated with carcinogens was significantly inhibited by treatment with CAP.
Positive_regulation (induction) of GST-P associated with qutenza
12) Confidence 0.35 Published 1991 Journal J. Korean Med. Sci. Section Abstract Doc Link 1888447 Disease Relevance 0.25 Pain Relevance 0.56
Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats.
Positive_regulation (Enhancement) of glutathione S-transferase placental in liver
13) Confidence 0.33 Published 1999 Journal Carcinogenesis Section Title Doc Link 9934864 Disease Relevance 0 Pain Relevance 0.06
Interestingly, Shi et al. [66] recently reported increased GSTp protein levels in synaptosomal fractions from the frontal cortices of patients with pathologically-verified PD and suggest that GSTp may be important in the progression of the disease.
Positive_regulation (increased) of GSTp protein associated with disease
14) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0.83 Pain Relevance 0.46
showed that all could suppress the formation of GSTp foci that were induced by
Positive_regulation (induced) of GSTp
15) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.58 Pain Relevance 0.04
GST-P–positive foci were induced by treatment with 2,4-DAT at a dose of 250 or 500 ppm and by the positive control treatment with DEN (Table 2).
Positive_regulation (induced) of GST-P
16) Confidence 0.18 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.23 Pain Relevance 0

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