INT171959

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Context Info
Confidence 0.34
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.03
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
osteoclasts 2
precursor cells 1
dendritic cell 1
T cell 1
Tnfrsf11a (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 99.08 Very High Very High Very High
rheumatoid arthritis 249 94.40 High High
Potency 5 90.72 High High
Peripheral nervous system 2 89.20 High High
metalloproteinase 55 86.32 High High
cytokine 221 85.08 High High
Inflammation 258 79.92 Quite High
Infliximab 6 71.76 Quite High
Arthritis 141 71.28 Quite High
Etanercept 7 71.16 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 83 98.42 Very High Very High Very High
Frontotemporal Dementia 6 97.24 Very High Very High Very High
Bone Disease 153 96.12 Very High Very High Very High
Muscle Disease 6 95.32 Very High Very High Very High
Syndrome 31 94.76 High High
Rheumatoid Arthritis 249 94.40 High High
Osteolysis 73 92.28 High High
Atherosclerotic Plaque 12 91.48 High High
Arthritis 167 88.64 High High
Apoptosis 69 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B; RANK-L, RANK-ligand; OPG, osteoprotogerin; VCP, valosin-containing protein; UPS, ubiquitin proteasome system; IKKß, I-?
RANK Binding (ligand) of
1) Confidence 0.34 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.12 Pain Relevance 0.08
B signalling pathway are not fully established, key steps (some with known dependence upon ubiquitylation) include (see Figure 1): engagement of RANK by RANK-L, which is antagonised by OPG-RANK-L binding; association of TRAF6 with activated RANK; binding of p62 to TRAF6; Lys63-linked autoubiquitylation of TRAF6, catalysed by its intrinsic E3 ubiquitin ligase activity; p62-aPKC-mediated phosphorylation and activation of I-?
RANK Binding (engagement) of associated with addiction
2) Confidence 0.34 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.05
For example, hormones, drugs or antibodies could be used (or have been applied) to regulate the expression of RANK-L and OPG, or binding of RANK-L to RANK (reviewed in [37] and discussed in [38]).
RANK-L Binding (binding) of
3) Confidence 0.33 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.17 Pain Relevance 0.04
Finally, a third category of drugs to treat prosthetic loosening are the biologics being developed that interfere with RANK/RANK-ligand signaling.
RANK Binding (interfere) of
4) Confidence 0.26 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129996 Disease Relevance 0.79 Pain Relevance 0.31
Osteoprotegerin (OPG) is a natural decoy receptor that binds to RANK ligand and prevents its interaction with RANK [42].
RANK Binding (interaction) of
5) Confidence 0.26 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129996 Disease Relevance 0.53 Pain Relevance 0.19
Finally, a third category of drugs to treat prosthetic loosening are the biologics being developed that interfere with RANK/RANK-ligand signaling.
RANK Binding (interfere) of
6) Confidence 0.26 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129996 Disease Relevance 0.79 Pain Relevance 0.31
Intriguingly, RANKL/RANK interactions also regulate T cell/dendritic cell communication, dendritic cell survival and lymphnode formation [35].
RANK Binding (interactions) of in T cell
7) Confidence 0.20 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 1.18 Pain Relevance 0.16
OPG inhibits bone resorption and binds with strong affinity to its ligand, RANKL, thereby preventing RANKL binding to its receptor, RANK [11,13,14].
RANK Binding (binding) of associated with hypercalcemia
8) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.96 Pain Relevance 0.36
This molecule is secreted by stromal cells and osteoblasts and competitively inhibits RANKL binding to RANK on the cell surface of osteoclast precursor cells and mature osteoclasts, thus inhibiting the osteoclastogenic actions of RANKL.
RANK Binding (binding) of in precursor cells
9) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.75 Pain Relevance 0.31
After the binding with RANK, several intracellular
RANK Binding (binding) of
10) Confidence 0.11 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 0.72 Pain Relevance 0.07
This effect is independent of RANKL/RANK interaction and is potentiated by IL-1.
RANK Binding (interaction) of
11) Confidence 0.08 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.87 Pain Relevance 0.31
Intriguingly, RANKL/RANK interactions also regulate T cell/dendritic cell communication, dendritic cell survival and lymphnode formation [35].
RANK Binding (interactions) of in dendritic cell
12) Confidence 0.07 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 1.18 Pain Relevance 0.16
B (RANK), a member of the TNF receptor family, primarily initiates a bone-degrading pathway and maturation of osteoclasts via its binding partner RANK ligand (RANKL).
RANK Binding (binding) of in osteoclasts
13) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.42 Pain Relevance 0.32
B (RANK), a member of the TNF receptor family, primarily initiates a bone-degrading pathway and maturation of osteoclasts via its binding partner RANK ligand (RANKL).
RANK Binding (binding) of in osteoclasts
14) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.41 Pain Relevance 0.31
Although, signals driven by Receptor Activator of NF-?
Receptor Activator Binding (driven) of
15) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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