INT171962

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 31.10
Pain Relevance 7.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
osteoclast 8
joints 4
bone marrow 3
synovial fluid 1
mammary glands 1
Tnfrsf11a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 703 100.00 Very High Very High Very High
rheumatoid arthritis 791 99.88 Very High Very High Very High
Arthritis 765 99.42 Very High Very High Very High
withdrawal 3 99.32 Very High Very High Very High
chemokine 68 97.24 Very High Very High Very High
Inflammation 683 94.72 High High
addiction 8 93.60 High High
agonist 20 92.76 High High
metalloproteinase 27 82.68 Quite High
Potency 2 71.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 157 100.00 Very High Very High Very High
Necrosis 75 100.00 Very High Very High Very High
Rheumatoid Arthritis 852 99.88 Very High Very High Very High
Osteoporosis 259 99.84 Very High Very High Very High
Breast Cancer 87 99.84 Very High Very High Very High
Hypercalcemia 284 99.60 Very High Very High Very High
Syndrome 78 99.44 Very High Very High Very High
Arthritis 906 99.42 Very High Very High Very High
Bone Disease 408 99.38 Very High Very High Very High
Metastasis 64 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of RANK signalling by RANK-L, a cytokine that is highly expressed in the bone marrow environment, can potentially lead to the activation of AP-1, NFATc1 and NF-?
Gene_expression (expressed) of RANK-L in bone marrow associated with cytokine
1) Confidence 0.72 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.64 Pain Relevance 0.05
Induction of RANK signalling by RANK-L, a cytokine that is highly expressed in the bone marrow environment, can potentially lead to the activation of AP-1, NFATc1 and NF-?
Gene_expression (signalling) of RANK in bone marrow associated with cytokine
2) Confidence 0.62 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.63 Pain Relevance 0.05
Although temporal aspects of the RANK-NF-?
Gene_expression (aspects) of RANK
3) Confidence 0.62 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.05
For example, hormones, drugs or antibodies could be used (or have been applied) to regulate the expression of RANK-L and OPG, or binding of RANK-L to RANK (reviewed in [37] and discussed in [38]).
Gene_expression (expression) of RANK-L
4) Confidence 0.62 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.18 Pain Relevance 0.04
A more complete and precise description of the molecular events that underlie RANK-NF-?
Gene_expression (underlie) of RANK
5) Confidence 0.62 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.19 Pain Relevance 0.15
The precise mechanism by which p62 mutations result in disordered RANK-NF-?
Gene_expression (result) of RANK
6) Confidence 0.62 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.41 Pain Relevance 0
B signalling axis) is indeed confirmed to be a reflection of disease-related events in vivo, the disease aetiology in PDB is likely to involve abnormal sensitivity of osteoclast RANK-NF-?
Gene_expression (sensitivity) of RANK in osteoclast associated with disease and bone disease
7) Confidence 0.62 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.26 Pain Relevance 0.05
It is questionable whether this normalisation was appropriate; indeed a recent study [23] indicated that ‘physiological’ expression (i.e. not over-expression) of mutant RANK in stably-transfected cell lines did not result in constitutive activation of NF-?
Gene_expression (expression) of RANK
8) Confidence 0.54 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.30 Pain Relevance 0
It will be important to know whether high-risk patients for skeletal metastases can be identified based on high RANK expression in their primary breast tumours.
Gene_expression (expression) of RANK associated with breast cancer and metastasis
9) Confidence 0.53 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.38 Pain Relevance 0
RANK ligand (also known as OPGL, ODF, and TRANCE) is an agoinst for RANK, and is expressed on osteoblasts and activated T cells [41]; it provides the essential signal for osteoclast differentiation and survival [27].
Gene_expression (expressed) of RANK in osteoclast
10) Confidence 0.46 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129996 Disease Relevance 0.61 Pain Relevance 0.30
RANKL binds to RANK, a member of the tumour necrosis factor receptor superfamily that is expressed on osteoclastic lineage cells [2,3].
Gene_expression (expressed) of RANK associated with necrosis, cancer and osteoporosis
11) Confidence 0.46 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.50 Pain Relevance 0.09
RANK ligand (also known as OPGL, ODF, and TRANCE) is an agoinst for RANK, and is expressed on osteoblasts and activated T cells [41]; it provides the essential signal for osteoclast differentiation and survival [27].
Gene_expression (expressed) of RANK in osteoclast
12) Confidence 0.41 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129996 Disease Relevance 0.68 Pain Relevance 0.31
Results shown in this report indicate that VIP reduces the expression of RANK and RANKL in the joints of arthritic mice, and may account for the bone protective properties of VIP in RA.
Gene_expression (expression) of RANK in joints associated with rheumatoid arthritis and arthritis
13) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.61 Pain Relevance 0.23
VIP has been reported to inhibit the expression of RANKL and RANK induced by vitamin D in mouse bone marrow cultures [28].
Gene_expression (expression) of RANK in bone marrow
14) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.56 Pain Relevance 0.27
VIP treatment of CIA mice resulted in a significant reduction in the expression of both RANK and RANKL, the mRNA levels of which in joints fell to near control values (non-CIA mice).
Gene_expression (expression) of RANK in joints associated with arthritis
15) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.94 Pain Relevance 0.44
Epithelial cells from normal mammary glands express RANK, and RANKL-RANK signalling is required for the development of lactating mammary glands during pregnancy [7].
Gene_expression (express) of RANK in mammary glands
16) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.08 Pain Relevance 0
Based on high constitutive RANK expression in breast cancer specimens and cell lines, recent data now indicate that the RANK expression status of cancer cells determines whether tumours predominantly migrate into bone, where the corresponding ligand RANKL is abundantly expressed [8].
Gene_expression (expression) of RANK associated with cancer and breast cancer
17) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.23 Pain Relevance 0
The correlation of high RANK expression with osteotropism in murine models was demonstrated across diverse tumour cell types, including breast cancer and melanoma [8].
Gene_expression (expression) of RANK associated with cancer, breast cancer and skin cancer
18) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.38 Pain Relevance 0
also stimulates osteoclast differentiation and bone resorption in vivo in a RANKL/RANK-dependent manner when it is expressed adjacent to bone surfaces [22].
Gene_expression (expressed) of RANK in osteoclast associated with hypercalcemia
19) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.05 Pain Relevance 0.11
RANKL binding to the RANK expressed on haematopoietic progenitors activates a signal transduction cascade that leads to osteoclast differentiation.
Gene_expression (expressed) of RANK in osteoclast
20) Confidence 0.33 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.85 Pain Relevance 0.14

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