INT171964

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2001
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.11
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joints 4
bone marrow 2
T cells 2
Tnfrsf11a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 133 99.32 Very High Very High Very High
chemokine 11 96.80 Very High Very High Very High
Arthritis 180 96.40 Very High Very High Very High
Inflammation 114 96.00 Very High Very High Very High
metalloproteinase 4 77.00 Quite High
cytokine 128 74.36 Quite High
Inflammatory mediators 15 49.80 Quite Low
Freund adjuvant 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 217 100.00 Very High Very High Very High
Rheumatoid Arthritis 133 99.32 Very High Very High Very High
Calcification 59 99.12 Very High Very High Very High
INFLAMMATION 120 91.44 High High
Osteoporosis 36 86.12 High High
Hypercalcemia 47 83.08 Quite High
Disease 21 81.52 Quite High
Aging 2 80.52 Quite High
Atherosclerosis 19 58.64 Quite High
Atherosclerotic Plaque 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VIP has been reported to inhibit the expression of RANKL and RANK induced by vitamin D in mouse bone marrow cultures [28].
Positive_regulation (induced) of Gene_expression (expression) of RANK in bone marrow
1) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.56 Pain Relevance 0.27
In the present study, we report a high level of RANK expression in the joints of arthritic mice, probably induced by the recruitment of osteoclast precursors induced by the local production of chemokines chemotactic for monocytes [51].
Positive_regulation (induced) of Gene_expression (expression) of RANK in joints associated with chemokine and arthritis
2) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.77 Pain Relevance 0.41
In the present study, we report a high level of RANK expression in the joints of arthritic mice, probably induced by the recruitment of osteoclast precursors induced by the local production of chemokines chemotactic for monocytes [51].
Positive_regulation (level) of Gene_expression (expression) of RANK in joints associated with chemokine and arthritis
3) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.77 Pain Relevance 0.40
might upregulate RANK and RANKL expression and signalling.
Spec (might) Positive_regulation (upregulate) of Gene_expression (expression) of RANK
4) Confidence 0.15 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 0.57 Pain Relevance 0.04
In this model, activated T cells express RANKL protein on their surface, and through binding of RANKL to RANK on preosteoclasts, these cells promote osteoclastogenesis and subsequent bone loss.
Positive_regulation (activated) of Gene_expression (protein) of RANK in T cells
5) Confidence 0.10 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 1.43 Pain Relevance 0.62

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox