INT171974

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 13.11
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
osteoclasts 3
dendritic cell 2
T cell 2
precursor cells 1
Tnfrsf11a (Mus musculus)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 282 94.64 High High
cytokine 267 89.36 High High
Peripheral nervous system 2 89.20 High High
Potency 3 87.04 High High
metalloproteinase 57 86.32 High High
Inflammation 364 77.76 Quite High
Arthritis 160 71.28 Quite High
methotrexate 8 60.40 Quite High
Intractable pain 1 58.84 Quite High
Infliximab 5 57.84 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 97 100.00 Very High Very High Very High
Cancer 57 99.28 Very High Very High Very High
Necrosis 26 99.00 Very High Very High Very High
Osteoporosis 287 96.68 Very High Very High Very High
Syndrome 14 95.08 Very High Very High Very High
Bone Disease 51 94.68 High High
Rheumatoid Arthritis 282 94.64 High High
Arthritis 188 88.88 High High
Apoptosis 80 87.88 High High
Disease 122 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RANKL binds to RANK, a member of the tumour necrosis factor receptor superfamily that is expressed on osteoclastic lineage cells [2,3].
RANK Binding (binds) of RANKL associated with necrosis, cancer and osteoporosis
1) Confidence 0.35 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.46 Pain Relevance 0.09
For example, hormones, drugs or antibodies could be used (or have been applied) to regulate the expression of RANK-L and OPG, or binding of RANK-L to RANK (reviewed in [37] and discussed in [38]).
RANK-L Binding (binding) of OPG
2) Confidence 0.34 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.18 Pain Relevance 0.04
Osteoprotegerin (OPG) is a natural decoy receptor that binds to RANK ligand and prevents its interaction with RANK [42].
RANK Binding (binds) of OPG
3) Confidence 0.18 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129996 Disease Relevance 0.53 Pain Relevance 0.22
This molecule is secreted by stromal cells and osteoblasts and competitively inhibits RANKL binding to RANK on the cell surface of osteoclast precursor cells and mature osteoclasts, thus inhibiting the osteoclastogenic actions of RANKL.
RANK Binding (binding) of RANKL in precursor cells
4) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.75 Pain Relevance 0.31
OPG inhibits bone resorption and binds with strong affinity to its ligand, RANKL, thereby preventing RANKL binding to its receptor, RANK [11,13,14].
RANK Binding (binding) of OPG associated with hypercalcemia
5) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 1.05 Pain Relevance 0.40
RANKL binding to the RANK expressed on haematopoietic progenitors activates a signal transduction cascade that leads to osteoclast differentiation.
RANK Binding (binding) of RANKL in osteoclast
6) Confidence 0.12 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.85 Pain Relevance 0.14
Intriguingly, RANKL/RANK interactions also regulate T cell/dendritic cell communication, dendritic cell survival and lymphnode formation [35].
RANK Binding (interactions) of RANKL in T cell
7) Confidence 0.09 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 1.18 Pain Relevance 0.16
Intriguingly, RANKL/RANK interactions also regulate T cell/dendritic cell communication, dendritic cell survival and lymphnode formation [35].
RANK Binding (interactions) of RANKL in T cell
8) Confidence 0.09 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 1.18 Pain Relevance 0.16
This effect is independent of RANKL/RANK interaction and is potentiated by IL-1.
RANK Binding (interaction) of RANKL
9) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.87 Pain Relevance 0.31
This effect is independent of RANKL/RANK interaction and is potentiated by IL-1.
RANK Binding (interaction) of RANKL
10) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.87 Pain Relevance 0.31
Intriguingly, RANKL/RANK interactions also regulate T cell/dendritic cell communication, dendritic cell survival and lymphnode formation [35].
RANK Binding (interactions) of RANKL in dendritic cell
11) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 1.18 Pain Relevance 0.16
Intriguingly, RANKL/RANK interactions also regulate T cell/dendritic cell communication, dendritic cell survival and lymphnode formation [35].
RANK Binding (interactions) of RANKL in dendritic cell
12) Confidence 0.03 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 1.18 Pain Relevance 0.16
B (RANK), a member of the TNF receptor family, primarily initiates a bone-degrading pathway and maturation of osteoclasts via its binding partner RANK ligand (RANKL).
RANK Binding (ligand) of RANKL in osteoclasts
13) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.43 Pain Relevance 0.33
B (RANK), a member of the TNF receptor family, primarily initiates a bone-degrading pathway and maturation of osteoclasts via its binding partner RANK ligand (RANKL).
RANK Binding (ligand) of RANKL in osteoclasts
14) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.40 Pain Relevance 0.31

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