INT171975

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Context Info
Confidence 0.05
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.24
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
endothelial cells 2
CPA 2
spinal cord 2
platelets 2
Kupffer cells 2
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 5 98.56 Very High Very High Very High
Arthritis 18 97.12 Very High Very High Very High
Spinal cord 177 96.90 Very High Very High Very High
Inflammation 64 96.72 Very High Very High Very High
cva 1 95.64 Very High Very High Very High
alcohol 79 91.80 High High
chemokine 5 91.24 High High
cytokine 40 88.72 High High
COX-2 inhibitor 6 88.56 High High
antagonist 5 84.92 Quite High
Disease Link Frequency Relevance Heat
Sepsis 51 100.00 Very High Very High Very High
Cancer 368 99.36 Very High Very High Very High
Colorectal Cancer 32 99.16 Very High Very High Very High
INFLAMMATION 66 98.16 Very High Very High Very High
Metastasis 109 97.92 Very High Very High Very High
Arthritis 25 97.12 Very High Very High Very High
Cv General 3 Under Development 1 95.64 Very High Very High Very High
Injury 15 95.16 Very High Very High Very High
Breast Cancer 35 85.88 High High
Rheumatoid Arthritis 33 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo acetaldehyde production after ethanol consumption is significantly reduced after a 3-day use of an antiseptic mouthwash (chlorhexidine) [144,145].
Negative_regulation (reduced) of Gene_expression (production) of In vivo
1) Confidence 0.05 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2596158 Disease Relevance 0.29 Pain Relevance 0.11
Preparation of platelets for in vitro study
Negative_regulation (Preparation) of Gene_expression (study) of in vitro in platelets
2) Confidence 0.04 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0 Pain Relevance 0.04
ALDH1 enzymatic activity, which is generally highest in CoCSC, appears to play a major role in mediating resistance to CPA, as its inhibition in vitro, and reduced expression in vivo, sensitizes colorectal tumor cells to the bioactive metabolite of CPA.
Negative_regulation (reduced) of Gene_expression (expression) of in vitro in CPA associated with colorectal cancer
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.93 Pain Relevance 0
Since reproducible cell transplantation into spinal cord is a relatively complex procedure, we first investigated whether subcutaneous cell transplantation might provide a valuable alternative in order to study persistence of transgene expression in vivo.
Negative_regulation (persistence) of Gene_expression (expression) of in vivo in spinal cord associated with spinal cord
4) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0.11
While in vivo EGFP mRNA and protein expression by transplanted hMSC-EGFP cells was readily detectable at different time points post-transplantation, in vivo NT3 mRNA expression by hMSC-NT3 cells and in vivo EGFP protein expression by hMSC-NT3-EGFP cells was, respectively, undetectable or declined rapidly between day 1 and 7 post-transplantation.
Negative_regulation (declined) of Gene_expression (expression) of in vivo
5) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Abstract Doc Link PMC2225398 Disease Relevance 0.13 Pain Relevance 0.16
While in vivo EGFP expression of transplanted hMSC-EGFP cells was readily detectable at different time points post-transplantation (Figure 2B), in vivo transgene expression by hMSC-NT3 and hMSC-NT3-EGFP cells was, respectively, undetectable (Figure 3) or declined rapidly between day 1 and 7 post-transplantation (Figure 4).
Negative_regulation (declined) of Gene_expression (expression) of in vivo
6) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.07 Pain Relevance 0.08
However, IL-18 also has a potentially beneficial role, as it may inhibit osteoclasto-genesis via GM-CSF production in vitro [52].
Spec (may) Negative_regulation (inhibit) of Gene_expression (production) of in vitro
7) Confidence 0.01 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.90 Pain Relevance 0.45
In vitro production of IL-6 by Kupffer cells after CLP was significantly reduced by in vivo NS-398 treatment.
Negative_regulation (reduced) of Gene_expression (production) of In vitro in Kupffer cells associated with sepsis
8) Confidence 0.01 Published 2004 Journal Crit Care Section Body Doc Link PMC1065065 Disease Relevance 1.25 Pain Relevance 0.35
in MDA-MB-231 cells decreased VEGF expression in vitro, and inhibited tumor angiogenesis at sites of bone metastasis in vivo, as demonstrated by CD31 staining for endothelial cells.
Negative_regulation (decreased) of Gene_expression (expression) of in vitro in endothelial cells associated with cancer and metastasis
9) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.66 Pain Relevance 0.04

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