INT171989

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 11.76
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ank) plasma membrane (Ank)
Anatomy Link Frequency
joint 1
articular cartilage 1
Ank (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 142 99.84 Very High Very High Very High
spinal inflammation 690 99.80 Very High Very High Very High
Arthritis 20 96.20 Very High Very High Very High
antagonist 1 95.40 Very High Very High Very High
Pain score 6 41.24 Quite Low
cytokine 19 14.44 Low Low
spondylitis 30 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ankylosis 31 100.00 Very High Very High Very High
Osteoarthritis 143 99.84 Very High Very High Very High
Seronegative Spondarthritis 690 99.80 Very High Very High Very High
Calcification 276 99.80 Very High Very High Very High
Chondrocalcinosis 19 99.48 Very High Very High Very High
Metaplasia 6 97.08 Very High Very High Very High
Arthritis 20 96.20 Very High Very High Very High
Aging 79 95.80 Very High Very High Very High
Diabetes Mellitus 13 95.52 Very High Very High Very High
Increased Venous Pressure Under Development 6 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Very little is known regarding the molecular mechanisms that underlie the regulation of ANKH expression.
Gene_expression (expression) of ANKH
1) Confidence 0.78 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.62 Pain Relevance 0.42
It is likely that the predisposing polymorphisms affect gender-specific regulation of ANKH expression.
Gene_expression (expression) of ANKH
2) Confidence 0.78 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.64 Pain Relevance 0.38
In view of the locations of the ANKH variants associated with AS, it remains unclear whether this ARE-like motif at the promoter region can directly contribute to the regulation of ANKH expression by the predisposing polymorphisms.
Gene_expression (expression) of ANKH associated with spinal inflammation
3) Confidence 0.78 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.69 Pain Relevance 0.47
Therefore, acquired regional and systemic decrements in NPP1 and ANK expression and extracellular PPi could contribute to intra-arterial chondroosseous metaplasia and calcification in aging, diabetes mellitus, and atherosclerosis.
Gene_expression (expression) of ANK associated with calcification, aging, diabetes mellitus, metaplasia and increased venous pressure under development
4) Confidence 0.72 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.12 Pain Relevance 0
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Gene_expression (expression) of ANK in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
5) Confidence 0.72 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.66 Pain Relevance 0.28
In this model, excess extracellular PPi also may result from heightened release of intracellular PPi via increased ANK expression in OA and abnormal ANK function in familial chondrocalcinosis, as well as from deficient activity of pyrophosphatases (such as TNAP and possibly inorganic pyrophosphatase) in certain primary metabolic disorders.
Gene_expression (expression) of ANK associated with chondrocalcinosis, metabolic disorder and osteoarthritis
6) Confidence 0.72 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.39 Pain Relevance 0.19
Thus, our analyses of 201 multiplex AS families showed that ANKH variants found in two different regions of the ANKH gene are modestly associated with AS.
Gene_expression (variants) of ANKH associated with spinal inflammation
7) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 1.02 Pain Relevance 0.97
All of the families were genotyped with 11 markers in the ANKH region (D5S1953, rs26307, rs27356, 3088132, rs153929, rs258215, rs28006, rs25957, ANKH-OR, D5S1991 and D5S1954).
Gene_expression (region) of ANKH
8) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.55 Pain Relevance 0.55
Nevertheless, the remarkable phenotypic similarities between NPP1-deficient and ANK-deficient mice strongly support the central role of NPP1 catalyzed PPi generation in the regulation of calcification.



Gene_expression (deficient) of ANK associated with calcification
9) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.38 Pain Relevance 0
In this model, excess extracellular PPi also may result from heightened release of intracellular PPi via increased ANK expression in OA and abnormal ANK function in familial chondrocalcinosis, as well as from deficient activity of pyrophosphatases (such as TNAP and possibly inorganic pyrophosphatase) in certain primary metabolic disorders.
Gene_expression (function) of ANK associated with chondrocalcinosis, metabolic disorder and osteoarthritis
10) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.33 Pain Relevance 0.16
NPP1 and ANK in PPi metabolism and calcification
Gene_expression (metabolism) of ANK associated with calcification
11) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.49 Pain Relevance 0
FBAT analyses showed two regions in the ANKH gene where associations between ANKH variants and AS were detected.
Gene_expression (variants) of ANKH associated with spinal inflammation
12) Confidence 0.59 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.65 Pain Relevance 0.65
Very recently, an elegant study in mice demonstrated that mutation at the progressive ankylosis (ank) locus, mapped to proximal mouse chromosome 15, causes a generalized progressive form of arthritis with mineral deposition, formation of bony outgrowths, and joint destruction.
Gene_expression (progressive) of ankylosis in joint associated with ankylosis and arthritis
13) Confidence 0.04 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 1.21 Pain Relevance 0.29

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