INT17199

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Context Info
Confidence 0.56
First Reported 1991
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 3.07
Pain Relevance 11.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cspg5) Golgi apparatus (Cspg5) endoplasmic reticulum (Cspg5)
plasma membrane (Cspg5)
Anatomy Link Frequency
neurons 2
spinal cord 2
amygdala 2
Cspg5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 32 100.00 Very High Very High Very High
Morphine 27 100.00 Very High Very High Very High
antagonist 9 99.98 Very High Very High Very High
lidocaine 16 99.76 Very High Very High Very High
opioid receptor 7 99.74 Very High Very High Very High
Nucleus accumbens 15 99.40 Very High Very High Very High
wide dynamic range 28 99.36 Very High Very High Very High
Dopamine 3 99.34 Very High Very High Very High
Ventral tegmentum 15 98.80 Very High Very High Very High
amygdala 12 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 99.40 Very High Very High Very High
Nociception 24 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine administration significantly decreased NGC mRNA levels in the NAc, striatum, VTA, and amygdala compared to acute treatment.
Negative_regulation (decreased) of NGC mRNA in amygdala associated with ventral tegmentum, nucleus accumbens, amygdala and morphine
1) Confidence 0.56 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16146580 Disease Relevance 0.17 Pain Relevance 1.77
Descending inhibition from the NGC/NGC alpha produced by electrical stimulation was attenuated or completely abolished by bilateral transection of the dorsolateral funiculi (DLF) of the cervical spinal cord.
Negative_regulation (inhibition) of NGC alpha in spinal cord associated with spinal cord
2) Confidence 0.43 Published 1991 Journal Brain Res. Section Abstract Doc Link 1888999 Disease Relevance 0.14 Pain Relevance 0.72
Dopamine and opioid receptor antagonists attenuated the effect of MAP and morphine respectively on NGC mRNA levels.
Negative_regulation (attenuated) of NGC mRNA associated with dopamine, antagonist, opioid receptor and morphine
3) Confidence 0.42 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16146580 Disease Relevance 0.15 Pain Relevance 1.73
No significant effect on nociceptive responses of WDR neurons per se was found after blocking the NRM, ipsilateral NGC, NGCalpha/NPGL, or all the NRM, ipsilateral NGC, and NGCalpha/NPGL with lidocaine.
Negative_regulation (blocking) of NGC in neurons associated with nociception, raphe magnus, lidocaine and wide dynamic range
4) Confidence 0.41 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12941375 Disease Relevance 0.57 Pain Relevance 1.30
Single MAP (acute MAP) administration significantly decreased NGC mRNA levels in the frontal cortex, ventral tegmental area (VTA), and amygdala compared to vehicle-treated groups.
Negative_regulation (decreased) of NGC mRNA in amygdala associated with ventral tegmentum, urological neuroanatomy and amygdala
5) Confidence 0.41 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16146580 Disease Relevance 0.18 Pain Relevance 1.14
Also, a similar effect was observed when all the NRM, ipsilateral NGC, NGCalpha and NPGL were blocked with lidocaine.
Negative_regulation (blocked) of NGC associated with raphe magnus and lidocaine
6) Confidence 0.18 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12941375 Disease Relevance 0.57 Pain Relevance 1.31
Descending inhibition from the NGC/NGC alpha produced by electrical stimulation was attenuated or completely abolished by bilateral transection of the dorsolateral funiculi (DLF) of the cervical spinal cord.
Negative_regulation (inhibition) of NGC in spinal cord associated with spinal cord
7) Confidence 0.18 Published 1991 Journal Brain Res. Section Abstract Doc Link 1888999 Disease Relevance 0.14 Pain Relevance 0.69
No significant effect on nociceptive responses of WDR neurons per se was found after blocking the NRM, ipsilateral NGC, NGCalpha/NPGL, or all the NRM, ipsilateral NGC, and NGCalpha/NPGL with lidocaine.
Negative_regulation (blocking) of NGCalpha in neurons associated with nociception, raphe magnus, lidocaine and wide dynamic range
8) Confidence 0.05 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12941375 Disease Relevance 0.57 Pain Relevance 1.30
Also, a similar effect was observed when all the NRM, ipsilateral NGC, NGCalpha and NPGL were blocked with lidocaine.
Negative_regulation (blocked) of NGCalpha associated with raphe magnus and lidocaine
9) Confidence 0.02 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12941375 Disease Relevance 0.57 Pain Relevance 1.30

General Comments

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