INT171994

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Context Info
Confidence 0.15
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
cytoplasm (DMD)
Anatomy Link Frequency
hip 2
vertebrae 2
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 44.84 Quite Low
Inflammation 10 11.36 Low Low
Osteoarthritis 56 5.00 Very Low Very Low Very Low
Pain 23 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Paracetamol 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
backache 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hip Fractures 16 92.56 High High
Hypercalcemia 38 89.76 High High
Postmenopausal Osteoporosis 16 87.48 High High
Osteoporosis 260 69.44 Quite High
Endometriosis (extended) 17 64.68 Quite High
Osteoporotic Fractures 26 54.32 Quite High
INFLAMMATION 8 44.60 Quite Low
Aseptic Necrosis Of Bone 6 33.12 Quite Low
Compression Fractures 10 30.48 Quite Low
Disease 30 13.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to the above studies, alendronate has been shown to be effective at increasing BMD of the spine and total hip and also reduces vertebral fractures in patients on long-term glucocorticoid therapy.
Regulation (effective) of Positive_regulation (increasing) of BMD in hip
1) Confidence 0.15 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.29 Pain Relevance 0
The increase in BMD was independent of baseline BMD.
Neg (independent) Regulation (independent) of Positive_regulation (increase) of BMD
2) Confidence 0.15 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0 Pain Relevance 0
Other bones scanned also showed that zoledronic acid was more effective at increasing BMD than risedronate.
Regulation (effective) of Positive_regulation (increasing) of BMD
3) Confidence 0.07 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998805 Disease Relevance 0.15 Pain Relevance 0
Compared with placebo, the changes in BMD induced by zoledronic acid were 6%, 5.1%, and 6.7% in the total hip, femoral neck, and lumbar vertebrae, respectively.
Regulation (changes) of Positive_regulation (induced) of BMD in vertebrae
4) Confidence 0.04 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998805 Disease Relevance 0.33 Pain Relevance 0
Other polymorphic genes, such as the one encoding ERa, have been shown to modulate the effect of the VDR gene in the determination of BMD, confirming the existence of gene?
Regulation (modulate) of Positive_regulation (determination) of BMD
5) Confidence 0.04 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.05 Pain Relevance 0

General Comments

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