INT171998

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2011
Negated 2
Speculated 4
Reported most in Body
Documents 58
Total Number 62
Disease Relevance 38.13
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
cytoplasm (DMD)
Anatomy Link Frequency
spine 9
hip 8
cartilage 1
platelet 1
osteoclast 1
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 41 100.00 Very High Very High Very High
fibrosis 115 99.68 Very High Very High Very High
alcohol 68 99.64 Very High Very High Very High
spinal inflammation 66 99.52 Very High Very High Very High
Osteoarthritis 226 98.36 Very High Very High Very High
backache 59 96.96 Very High Very High Very High
Inflammation 62 96.68 Very High Very High Very High
anticonvulsant 20 90.76 High High
corticosteroid 42 86.24 High High
carbamazepine 17 85.44 High High
Disease Link Frequency Relevance Heat
Disease 809 100.00 Very High Very High Very High
Obesity 215 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 170 100.00 Very High Very High Very High
Prostate Cancer 129 100.00 Very High Very High Very High
Endometriosis (extended) 163 99.98 Very High Very High Very High
Osteoporosis 2003 99.88 Very High Very High Very High
Osteoporotic Fractures 173 99.80 Very High Very High Very High
Cystic Fibrosis 110 99.68 Very High Very High Very High
Postmenopausal Osteoporosis 107 99.68 Very High Very High Very High
Hypertension 50 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localisation of dystrophin to the sarcolemma suggests appropriate interaction with other proteins of the dystrophin glycoprotein complex.
dystrophin Binding (interaction) of
1) Confidence 0.47 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.13 Pain Relevance 0
Sarcolemmal colocalisation of dystrophin with other proteins of the dystrophin glycoprotein complex (webappendix) suggested that dystrophin interacted with other members of this protein complex and was therefore presumed to be functional.
dystrophin Binding (interacted) of
2) Confidence 0.47 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.06 Pain Relevance 0
Other C-terminal isoforms of dystrophin due to differential promoter usage and/or alternative splicing at the 3?
dystrophin Binding (splicing) of
3) Confidence 0.36 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2042511 Disease Relevance 1.08 Pain Relevance 0.03
Recent studies showed a role for dystrophin in normal controls during platelet spreading and adhesion by regulating the ?
dystrophin Binding (role) of in platelet associated with adhesions
4) Confidence 0.36 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2042511 Disease Relevance 1.03 Pain Relevance 0
Dystrophin associates with other sarcolemmal proteins of the dystrophin glycoprotein complex and connects the cytoskeleton to the extracellular matrix.
Dystrophin Binding (associates) of in extracellular matrix
5) Confidence 0.36 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.81 Pain Relevance 0
Immunohistochemical stainings for dystrophin, merosin, dysferlin and sarcoglycans revealed one case of Duchenne muscular dystrophy (DMD; MIM#310200) in carrier state, one case of merosinopathy (MDC1A; MIM#607855), and seven cases of dysferlinopathy (LGMD2B; MIM# 253601), leaving 26 patients to be studied with western blot analysis.


dystrophin Binding (stainings) of associated with muscular dystrophy
6) Confidence 0.36 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693639 Disease Relevance 0.56 Pain Relevance 0
Besides, dysbindin also binds to the dystrophin-associated protein complex (DPC), a component of the synapse (Benson et al., 2001).
dystrophin Binding (binds) of in synapse
7) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0.03
To answer these questions, we examined the association between MRI-determined LDD and BMD assessed at the lumbar spine and hip in a large community based sample of UK female twins.


BMD Spec (examined) Binding (association) of in hip associated with disease
8) Confidence 0.31 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002767 Disease Relevance 1.03 Pain Relevance 0.18
The association between LDD and BMD is mediated, at least partially, by shared genetic factors, consistent with previously reported findings that peak bone mass is increased in the hip in daughters of women with OA.24 It is, of course, of great interest to identify molecular mechanisms causing such a correlation.
BMD Binding (association) of in hip associated with disease and osteoarthritis
9) Confidence 0.31 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002767 Disease Relevance 0.72 Pain Relevance 0.05
The multivariate multiple regression analysis showed highly significant association (overall p<0.001) of the LDD and its structural components with age, lumbar spine BMD (as well as with hip BMD, not shown), body weight and exercise.
BMD Binding (association) of in hip associated with body weight and disease
10) Confidence 0.31 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002767 Disease Relevance 0.94 Pain Relevance 0
Component traits of MRI-determined LDD (disc height, disc signal, anterior osteophytes and disc bulge) were examined individually: association with lumbar spine BMD was identified for all of them (table 2), particularly disc height.
BMD Binding (association) of in spine associated with osteophyte and disease
11) Confidence 0.30 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002767 Disease Relevance 0.99 Pain Relevance 0.18
A clear, significant and independent association of BMD at hip and lumbar spine with LDD was found which is, in part, genetically mediated.
BMD Spec (clear) Binding (association) of in spine associated with disease
12) Confidence 0.30 Published 2010 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC3002767 Disease Relevance 0.87 Pain Relevance 0.21
LDD is reported in small studies to be associated with increased spine bone mineral density (BMD).
BMD Binding (associated) of in spine associated with disease
13) Confidence 0.30 Published 2010 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC3002767 Disease Relevance 1.05 Pain Relevance 0.33
In testing association with lumbar spine BMD, we found that phenotypic correlation observed between these two traits is attributable to common genes (RG=0.232±0.050) and shared environmental factors (RE=0.205±0.074), p<0.005 by likelihood ratio test.
BMD Binding (association) of in spine
14) Confidence 0.30 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002767 Disease Relevance 1.04 Pain Relevance 0.06
Since triglycerides were not associated with spine BMD, their direct contribution to fracture risk, if any, is via modulation of bone quality or bone strength.
BMD Binding (associated) of in spine
15) Confidence 0.24 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 0.29 Pain Relevance 0
Several studies have shown back extensor strength decreases with age 17, 47, 83 and has an inverse relationship with BMD 74, 86, 83, 91, both of which are established correlates of osteoporosis.
BMD Binding (relationship) of associated with osteoporosis
16) Confidence 0.19 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074712 Disease Relevance 0.69 Pain Relevance 0.06
Our multiple regression analyses could not reveal significant independent associations of any of the considered lipid and lipoprotein components with hip or spine BMD.
BMD Binding (associations) of in spine
17) Confidence 0.19 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 0.54 Pain Relevance 0
Since the association of lipids and lipoproteins to BMD and non-vertebral fractures is not independent of the severity of AC, it seems unlikely that these metabolites exert direct and clinically significant effects on bone turnover in postmenopausal women.
BMD Binding (association) of associated with calcification
18) Confidence 0.18 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 1.01 Pain Relevance 0
Although some smaller cross-sectional studies found associations between lipid profile and BMD in humans [15–17], neither large population-based studies (e.g., NHANES III) nor prospective studies support these initial observations [18, 19].
BMD Binding (associations) of
19) Confidence 0.18 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 0.95 Pain Relevance 0
Treated hypertension was significantly associated with spine BMD, whereas the severity score of AC was a significant inverse correlate of hip BMD (p?
BMD Binding (associated) of in hip associated with calcification and hypertension
20) Confidence 0.18 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 1.10 Pain Relevance 0.05

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